We have previously shown that intraperitoneal vaccination with the recombinant N terminus of Als1p (rAls1p-N) modestly improves survival during murine disseminated candidiasis. We now report marked efficacy with subcutaneous rAls1p-N vaccination. Efficacy is retained in neutropenic and corticosteroid-treated mice. The rAls1p-N vaccine is a promising candidate for the prevention of invasive cand...

We demonstrated 2 different antibodies against Candida albicans in patients' sera, the detection rates were proportional to the severity of candidiasis. One antibody was directed toward antigen shared by Candida in both blastospore and mycelial phases and the other was directed against antigen found only in the mycelial phase of Candida. The presence of the latter may reflect the invasive form...

Candida infections are very common in cancer patients and it is a common practice to prescribe antifungal antibiotics along with anticancer drugs. Yeast to hyphal form switching is considered to be important in invasive candidiasis. Targeting morphogenetic switching may be useful against invasive candidiasis. In this study, we report the antimorphogenetic properties of thirty cancer drugs.

background: vulvovaginal candidiasis is the most common fungal disease in sexually active women of which candida albicans is the primary etiologic agent. materials and methods: this cross-sectional study was performed to determine the etiologic agents of vulvovaginal candidiasis amongst 2000 women who presented to the gynecological center of babol shahid yahyanejad educational hospital from 200...

Introduction: In recent years, more and people have become infected with Human Immunodeficiency Virus. Of great importance in the course of HIV infection are symptoms diseases, which often occurs oral cavity a corresponding decrease lymphocytes.Aim: The aim study was to present most common diseases patients Virus like hairy leukoplakia, Candidas, angular cheilitis, Linear Gingival Erythema, Her...

Two randomized, placebo-controlled trials previously showed that fluconazole (400 mg/d) administered prophylactically decreases the incidence of candidiasis in blood and marrow transplant (BMT) recipients. However, there exists conflicting data regarding the optimal duration of fluconazole administration, specifically whether prophylaxis through acute graft-versus-host disease (GVHD) results in...

Vulvovaginal candidiasis is the second most common cause of vaginitis after bacterial vaginosis with at least 75 – 80% women have had one episode VVC in their lifetime. Their prevalent resistance to commonly used antifungal agents makes treatment a challenge physicians. Flavonoids been shown possess potent anti-Candida properties which can inhibit growth and proliferation Candida species throug...

background a fungal infection represents a growing problem in children with hematologic malignancies,during chemotherapy induced neutropenia.fungal colonization is considered a major riskfactor for subsequent fungal infections. the aim of this retrospective study was to evaluate prevalence of fungal infection among children admitted to hospital between 2005 and 2010 in tehran, iran. materials a...

conclusions while bdg assay seems to be a sensitive and specific adjunctive tool to diagnose and monitor the experimental systemic candidiasis, it seems that measuring the positive cutoff value in different laboratory conditions is necessary for favorable establishment of these tests. results all the infected rats were positive with bdg tests. an increasing level of bdg was observed during earl...

the aim of this study was to investigate the immunomodulatory effects of spirulina platensis (s.platensis) by measuring the levels of serum interleukin (il)-4, il-10, il-17, tumor necrosis factor(tnf)-α and interferon (ifn)-|γ| in mice suffered from systemic candidiasis and breast cancer. theaqueous extract of s. platensis was selected for this study. balb/c female mice were inoculated withcand...