INTRODUCTION Amphotericin B (AMB) is an antifungal agent used extensively in clinical medicine, yet resistance remains low. This study aims to evaluate the susceptibility of Candida spp. against AMB. METHODS For broth microdilution susceptibility testing, 77 strains of Candida spp. were selected (32 C. albicans, 33 C. tropicalis, and 12 C. parapsilosis). The strains were considered susceptibl...

Demystification of microbial behaviour in mixed biofilms could have a major impact on our understanding of infectious diseases. The objectives of this study were to evaluate in vitro the interactions of six different Candida species and a Gram-negative coliform, Escherichia coli, in dual-species biofilms, and to assess the effect of E. coli LPS on Candida biofilm formation. A single isolate of ...

Fifteen 7-chloro-4-arylhydrazonequinolines have been evaluated for their in vitro antifungal activity against eight oral fungi: Candida albicans, C. parapsilosis, C. lipolytica, C. tropicalis, C. famata, C. glabrata, Rhodutorula mucilaginosa, and R. glutinis. Several compounds exhibited minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) activities comparable with ...

Candida parapsilosis has emerged as an important yeast species causing fungemia. We describe the incidence and epidemiology of C. parapsilosis fungemia. Data from active population-based surveillance in Barcelona, Spain, from January 2002 to December 2003 were analyzed. We focused on 78 episodes of C. parapsilosis fungemia, and we compared them with 175 Candida albicans controls. C. parapsilosi...

75 INTRODUCTION Fungi are reported to be responsible for 1.45 of all cases of endocarditis. More than half of all fungal endocarditis (FE) are caused by Candida species and Candida albicans is the most frequently isolated pathogen. The frequency of non albicans Candida endocarditis is increasing and C. parapsilosis is the predominant agent among these. We report a case of FE in a patient of rhe...

Background and Objectives Colonization of Candida species is common in pediatric patients admitted to hematology-oncology wards. The aim of this study was to identify colonized Candida species and their susceptibility patterns in hematologic pediatric patients. Materials and Methods Samples were collected from mouth, nose, urine and stool of the patients admitted to five university hospitals ...

BACKGROUND Cases of superficial and invasive mycoses caused by emerging species of Candida have been increasingly reported over the last thirty years. The production of hydrolytic enzymes plays a central role in the fungal infective process. In Candida infections the secretion of both proteases and phospholipases are well-known virulence attributes. AIMS To determine the protease and phosphol...

OBJECTIVE To assess the epidemiology of neonatal Candida blood stream infection. METHODS Medical records of neonates with Candida blood stream infection over 5 years (September 2010 to August 2015) were reviewed. Clinical details, species distribution and antifungal susceptibility were noted. RESULTS 114 neonates developed Candida blood stream infection. Commonly isolated Candida species we...

Relative to the vast data regarding virulence mechanisms of Candida albicans, there is limited knowledge on emerging opportunistic human pathogen parapsilosis. The aim this study was generate and characterize an overexpression mutant collection identify explore factors in C. With obtained mutants, we investigated stress tolerance, morphology switch, biofilm formation, phagocytosis, vivo Galleri...

Proteinase, lipase and alpha-glucosidase activity in 81 clinically isolated Candida strains grown in nutrient-restricted media were comparatively measured, and the correlation between inducible enzyme activity and fungal growth was analyzed. Enzyme activity was assayed by colorimetric methods. Extracellular proteinase activity was significantly higher in Candida albicans, followed by C. parapsi...