introduction exposure to chronic levels of ionizing radiation could be detrimental to health even at very low doses. calabar free trade zone (cftz) was established to promote export business in nigeria and it is yet to produce exposure data of the zone. materials and methods the zone was divided into three categories depending on the type of business. category a had facilities with manufacturin...

background: thyroid cancer is the most common endocrine malignancy. several risk factors were found to play a role in thyroid cancer. the purpose of the study was to determine the risk factors for thyroid cancer, in babol, north of iran. method: 80 patients with thyroid cancer were selected as case group and 160 people living in the neighborhood of the patients as control group. risk factors in...

: The idea of stem cells as being progenitors of cancer was initially controversial, but later supported by research in the field of leukemia and solid tumors. Afterwards, it was established that genetic abnormalities can affect the stem and progenitor cells, leading to uncontrolled replication and deregulated differentiation. These alterations will cause the changeover to cancerous stem cells ...

The accumulation of potentially toxic elements (PTEs) in water, soil and vegetables can pose a severe threat to the respective organisms lead human health risks upon exposure. Water, vegetable samples were collected from Mokolo River its vicinity. Total concentration quantification speciation analysis chromium (Cr) arsenic (As) performed using inductively coupled plasma-mass spectrometry (ICP-M...

pollution of water and soils by heavy metals is an emerging problem in industrialized countries.the present study was conducted to investigate the heavy metals concentration in water and sedimentsamples from ship breaking sites of sitakunda to assess the potential ecological risk posed by heavy metalusing different methods. heavy metals concentration was analyzed by atomic absorption spectrosco...

Prostate cancer (PC) is the most frequently diagnosed cancer in men. The acquisition of castration-resistant (CR) phenotype is associated with the activation of signaling pathways mediated by growth factors. The TGFβ1 and its receptors have an important role in tumor progression, being the pro-apoptotic function modulated by the expression of TGFBR2. A single nucleotide polymorphism -875 G > A ...

BACKGROUND Weight gain often occurs after breast cancer (BC) diagnosis and obesity along with sedentary behavior are associated with increased risk of BC recurrence and mortality. The primary objective of this study was to determine whether a significant weight loss, of approximately 10%, would lead to beneficial changes in biomarkers associated with cancer and/or cancer recurrence, and quality...

background: th e second leading cause of cancer deaths in women is breast cancer. germline mutations in susceptibility breast cancer gene brca1 increase the lifetime risk of breast cancer. eighty-one large genomic rearrangements (lgrs) have been reported up to date in brca1 gene, and evaluation of these rearrangements helps with precise risk assessment in high-risk individuals. in this study, w...

BACKGROUND Subjects with breast cancer enrolled in trials may experience multiple events such as local recurrence, distant recurrence or death. These events are not independent; the occurrence of one may increase the risk of another, or prevent another from occurring. The most commonly used Cox proportional hazards (Cox-PH) model ignores the relationships between events, resulting in a potentia...

This study was conducted to estimate true incidence of the total number of cancer cases and of cancers at selected sites in the population of Aichi Prefecture, Japan, using the degree of completeness of registration (CR). Information on incidence (I), death (D), and cases first notified via death certificate (DCN) was based on the data from 1976 to 1993. Using this information, CR for each canc...