PURPOSE Development of adenocarcinoma (AC) of the uterine cervix, as well as squamous cell carcinoma (SCC), is strongly linked to infection by high-risk human papillomavirus (HPV) types. Human HPV E6 and E7 proteins inactivate the tumor suppressor genes p53 and retinoblastoma, respectively. However, additional genetic alterations may be required to maintain a malignant phenotype. Allelic loss a...

The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteers were enrolled. Peripheral blood was collected, separated and centrifuged; DN...

OBJECTIVE The purposes of this study were to establish intracervical tumors of the nude rat as an orthotopic experimental model for human cervical cancer and to preliminary evaluate the effects of the adenoviral vector, Ad5CMV-p53, on orthotopic cervical tumor size. METHODS Human cervical cancer SiHa and ME-180 cells were injected into the cervix of the nude rat. Four days later, 1 x 10(9) pl...

e15518 Background: This study was carried out to highlight the prevalence of cancer of the uterine cervix and shortcoming in the management of cervical cancer in our hospital. There is the need to improve on our personnel training and equipment acquisition. METHODS This was a retrospective study. Case folders of forty-seven patients who were diagnosed with cancer of the cervix were retrieved ...

Background: Cervical cancer is an excessive abnormal cell growth around the cervix area. wascaused by many factors, and Human Papillomavirus (HPV) plays important role in of cervical cancer. HPV vaccine a major note reducing incidence rate The interest vaccination was affected level knowledge cancer.Objective: To show correlation between HPVvaccination students Medical Faculty HKBP Nommensen Me...

PURPOSE In clinical practice, radiation therapy often fails in cervical carcinoma stage IIIB and there is a need to develop a predictive assay for prognosis of radiation treatment outcome in cancer patient. We have attempted to evaluate the relevance of changes in Membrane Fluidity (MF) and associated apoptotic cell death in cervical cancer cells after first fractionated dose of radiation thera...

PURPOSE To proof feasibility of hydrogel application in patients with advanced cervical cancer undergoing chemo-radiation in order to reduce rectal toxicity from external beam radiation as well as brachytherapy. MATERIAL AND METHODS Under transrectal sonographic guidance five patients with proven cervical cancer underwent hydro gel (20 cc) instillation into the tip of rectovaginal septum adhe...

introduction: papsmear test has been performed by public health services since 1991 in iran.   although cervix cancer is reported 9 th cause of death in four studied counrties in 1999, unfortunately detection rate of smear test is reported very low.  the aim of this study was to determine the cause of low sensitivity of papsmear in hamadan province- north west of iran. materials and methods : 1...