نتایج جستجو برای: calpain

تعداد نتایج: 5210  

Journal: :Journal of neurochemistry 1997
I Hajimohammadreza K J Raser R Nath R Nadimpalli M Scott K K Wang

Calpain (calcium-activated neutral protease) has been implicated as playing a role of neuronal injury in cerebral ischemia and excitotoxicity. Here we report that, in addition to extreme excitotoxic conditions [N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainate challenges], other neurotoxins such as maitotoxin, A23187, and okadaic acid also...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Min-Jung Kim Dong-Gyu Jo Gil-Sun Hong Byung Ju Kim Michael Lai Dong-Hyung Cho Ki-Woo Kim Arun Bandyopadhyay Yeon-Mi Hong Do Han Kim Chunghee Cho Jun O Liu Solomon H Snyder Yong-Keun Jung

Cain/cabin1 is an endogenous inhibitor of calcineurin (Cn), a calcium-dependent serine/threonine phosphatase involved in various cellular functions including apoptosis. We show here that during apoptosis cain/cabin1 is cleaved by calpain at the carboxyl terminus to generate a cleavage product with a molecular mass of 32 kDa as a necessary step leading to Cn-mediated cell death. Mouse cain/cabin...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1995
C L Edelstein E D Wieder M M Yaqoob P E Gengaro T J Burke R A Nemenoff R W Schrier

The role of the lysosomal proteases cathepsins B and L and the calcium-dependent cytosolic protease calpain in hypoxia-induced renal proximal tubular injury was investigated. As compared to normoxic tubules, cathepsin B and L activity, evaluated by the specific fluorescent substrate benzyloxycarbonyl-L-phenylalanyl-L-arginine-7-amido-4-methylcoumarin, was not increased in hypoxic tubules or the...

Journal: :Neuroscience 2009
R J Grant L H L Sellings S J Crocker E Melloni D S Park P B S Clarke

The neurotoxin 6-hydroxydopamine has been widely used to model aspects of Parkinson's disease in rodents, but the mechanisms underlying toxin-induced dopaminergic degeneration and functional impairment have not been fully elucidated. The main aim of the present study was to assess a possible role for calpains in neurochemical and behavioral deficits following unilateral infusion of intrastriata...

Journal: :Hippocampus 2010
N Crespo-Biel A Camins J Gutiérrez-Cuesta D Melchiorri F Nicoletti M Pallàs A M Canudas

Glycogen synthase kinase-3beta (GSK-3beta) is a crucial component in the cascade of events that culminate in a range of neurodegenerative diseases. It is controlled by several pathways, including calpain-mediated cleavage. Calpain mediates in cell death induced by 3-nitropropionic acid (3-NP), but GSK-3beta regulation has not been demonstrated. Here we studied changes in total GSK-3beta protein...

Journal: :International Journal of Biological Sciences 2008
Yao-Yuan Hsieh Chi-Chen Chang Kung-Hao Hsu Fuu-Jen Tsai Chih-Ping Chen Horng-Der Tsai

Exercise training plays a major role in the improving physiology of diabetes. Herein we aimed to investigate the influence of exercise upon the calcium-dependent calpain-isoform expressions of lean or obese Zucker rats, a model of obesity and type II diabetes (NIDDM). Five-month-old rats were divided: (1) obese sedentary (OS, n=7); (2) obese exercise (OE, n=7); (3) lean sedentary (LS, n=7); (4)...

Journal: :Cardiovascular research 2004
Javier Inserte David Garcia-Dorado Marisol Ruiz-Meana Luis Agulló Pilar Pina Jordi Soler-Soler

OBJECTIVES It has been shown that sarcolemmal rupture can occur during reenergization in cardiomyocytes in which previous ischemia has induced sarcolemmal fragility by calpain-dependent hydrolysis of structural proteins. We tested the hypothesis that attenuated calpain activation contributes to the protection against reperfusion-induced cell death afforded by ischemic preconditioning (IPC), and...

Journal: :International journal of cancer 2008
Lei Liu Da Xing Wei R Chen Tongsheng Chen Yihui Pei Xuejuan Gao

Cisplatin is an efficient anticancer agent. Cisplatin-based chemotherapy is believed to involve different signal transduction pathways, among which calpain activation has been proposed as an important factor in the induced apoptosis. In our study, based on real-time single cell analysis, we investigated the molecular involvement of calpain in cisplatin-induced apoptosis in living human lung ade...

2015
Aysegul Yildiz-Unal Sirin Korulu Arzu Karabay

Calpains are calcium-dependent proteolytic enzymes that have deleterious effects on neurons upon their pathological over-activation. According to the results of numerous studies to date, there is no doubt that abnormal calpain activation triggers activation and progression of apoptotic processes in neurodegeneration, leading to neuronal death. Thus, it is very crucial to unravel all the aspects...

Journal: :American journal of physiology. Renal physiology 2001
X Liu J J Rainey J F Harriman R G Schnellmann

The goals of this study were to determine 1) the expression of calpain isoforms in rabbit renal proximal tubules (RPT); 2) calpain autolysis and translocation, and calpastatin levels during RPT injury; and 3) the effect of a calpain inhibitor (PD-150606) on calpain levels, mitochondrial function, and ion transport during RPT injury. RT-PCR, immunoblot analysis, and FITC-casein zymography demons...

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