نتایج جستجو برای: calcium plaque
تعداد نتایج: 201165 فیلتر نتایج به سال:
BACKGROUND Coronary computed tomographic angiography (CCTA) facilitates comprehensive evaluation of coronary artery disease (CAD), including plaque characterization, and can provide additive diagnostic value to single-photon emission computed tomography (SPECT). However, data regarding the incremental prognostic value of CCTA to SPECT remain sparse. We evaluated the independent and incremental ...
BACKGROUND Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Aortic elasticity and diastolic functions are helpful parameters in assessment of CAD. In this study we aimed to learn whether diastolic function and aortic elastic properties measured by echocardiography are associated with coronary calcium score (CACS), epicardial fat volume (EFV), and plaque a...
The rupture of a vulnerable coronary atherosclerotic plaque results in coronary thrombosis, the main cause of unstable angina, acute myocardial infarction, and sudden cardiac death. Usually, a culprit plaque that ultimately ruptures does not cause significant flow-limiting stenosis, but is characterized by a typical histological structure: it contains a large necrotic lipid core and a thin fibr...
One of the main causes of mortality is atherosclerosis which leads to sudden cardiac attack. Frequently the first symptom of coronary artery disease is acute coronary syndromes (ACS) which is mainly caused by the rupture of a coronary artery. Histopathological studies have revealed that generally atherosclerotic plaque rupture results in thrombi. Atherosclerosis components of clinical importanc...
Background: There is conflicting evidence for the link between calcification and plaque instability. Intravascular ultrasound (IVUS) studies have shown that calcified plaques are associated with stable plaques. In contrast, recent histopathological studies have revealed that plaque calcification is present in 69% of ruptured plaques in sudden coronary death. Furthermore, studies using electron-...
Mechanism of action of the growth hormone secretagogue, L-692,585, on isolated porcine somatotropes.
The effects of a GH secretagogue, L-692,585 (L-585), and human GH-releasing hormone (hGHRH) on calcium transient and GH release were investigated in isolated porcine pituitary cells using calcium imaging and the reverse hemolytic plaque assay (RHPA). Somatotropes were functionally identified by the application of hGHRH. All cells that responded to hGHRH responded to L-585 application. Perfusion...
PURPOSE To evaluate the impact of pre-procedural coronary plaque composition assessed by virtual histology intravascular ultrasound (VH-IVUS) on late stent malapposition assessed by optical coherence tomography (OCT) following drug-eluting stent (DES) implantation. MATERIALS AND METHODS The study population consisted of 121 patients (121 lesions) who underwent both pre-procedural VH-IVUS and ...
OBJECTIVES The aim of this study was to understand the initial mechanism of arterial thrombus formation induced by vulnerable human atherosclerotic plaques to re-assess and improve current antithrombotic strategies. BACKGROUND Rupture of atherosclerotic plaques causes arterial thrombus formation that might lead to myocardial infarction and ischemic stroke. Atherothrombosis is considered as an...
BACKGROUND Previous studies have reported diffuse destabilization of atherosclerotic plaques in acute myocardial infarction (AMI). We used intravascular ultrasound (IVUS) to assess coronary culprit lesions in ST segment elevation MI (STEMI) vs. in non-ST segment elevation MI (NSTEMI). METHODS Patient population comprised 125 STEMI and 185 NSTEMI patients. IVUS findings included ruptured plaqu...
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