Endothelin-1 (ET) induces increases in intracellular Ca(2+) concentration ([Ca(2+)](i)), Ca(2+) sensitization, and contraction of both bronchiole and pulmonary arteriole smooth muscle cells (SMCs) and may play an important role in the pathophysiology of asthma and pulmonary hypertension. However, because it remains unclear how changes in [Ca(2+)](i) and the Ca(2+) sensitivity regulate SMC contr...

background: while traditional semen parameters are of significant clinical value, total fertilization failure in ivf cycles is not uncommon. sperm function testing such as; hamster egg penetration test has severed limitations as a clinical test. the aim of this study was to evaluate the predictive value of semen parameters by using of intracellular calcium [ca2+]i increase in response to proges...

introduction: we investigated the role of atp-sensitive potassium channels and l-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. methods: we used a hotplate apparatus to assess pain behavior in male nmri mice. nociceptive sensitization was induced by three days injection of morphine and five days of drug free. on day 9 of the schedule, pain behavior test ...