BACKGROUND Ischemic stroke is a major health problem. Data regarding the possible association between ischemic stroke and the polymorphism of methylenetetrahydropholate reductase (MTHFR) C677T and A1298C are still conflictual. AIM The study tried to assess the association of the two MTHFR polymorphisms with ischemic stroke in a series of patients from a unique hospital center. MATERIALS AND...

We analyzed the role of the C677T polymorphism of the 5,10-methylenetetrahydrofolate and the A66G polymorphism of the methionine synthase reductase genes as risk factors for occurrence of spina bifida. The studied population included 106 mothers and 104 children from affected families, and a control group of 100 adults. We found statistically significant differences between the occurrence of th...

There are several evidences supporting the role of 5-10 methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in breast cancer (BC). Case control association studies on breast cancer have been repeatedly performed over the last two decades, but results are inconsistent. We performed a meta-analysis to confirm the association between MTHFR C677T polymorphism and BC risk. The articles we...

BACKGROUND The MTHFR C677T single nucleotide polymorphism TT genotype is associated with increased levels of plasma homocysteine and possibly an effect on cardiovascular mortality. We evaluated the effect of C677T genotype on mortality in a large end-stage renal disease (ESRD) cohort. METHODS C677T genotype was determined in 439 Caucasians with end-stage diabetic nephropathy (DNP) (cases) rec...

The role of methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C, methioninesynthase reductase (MTRR) A66G was unclear in repeated spontaneous abortion. To provide experimental basis for etiological diagnosis and treatment of recurrent spontaneous abortion, we selected 197 patients with recurrent spontaneous abortion and 116 normal women, extracting the oral mucosal epithelial cells and de...

Mục tiêu: 1) Xác định tỷ lệ một số biến thể di truyền gây tăng nguy cơ huyết khối trên phụ nữ mất thai tái diễn. 2) Bước đầu tìm hiểu mối liên quan giữa những với lần thai. Đối tượng và phương pháp nghiên cứu: sử dụng mô tả hồi cứu 306 có tiền diễn - RPL (mất từ 2 trở lên) chưa xác được nguyên nhân kết quả xét nghiệm 6 hay gặp 5 gen bằng bộ kít Devyser Thrombophilia đã đạt chứng nhận CE-IVD. Kế...