Purpose of the study. The assessment diabetes mellitus (DM) effect on levels sex hormones in tumor and peritumoral tissues BALB/c Nude mice with Lewis lung carcinoma (LLC). Materials methods . study included 42 male female aged 8–9 weeks weighing 21–22 g. Alloxan-induced DM was reproduced main group, then LLC transplanted. Levels estrone (E1), estradiol (E2), testosterone (T), progesterone (P4)...

The R- and S-enantiomers of 4-amino-3-hydroxybutanoic acid (GABOB) were full agonists at human recombinant rho1 GABA(C) receptors. Their enantioselectivity (R>S) matched that reported for their agonist actions at GABA(B) receptors, but was the opposite to that reported at GABA(A) receptors (S>R). The corresponding methylphosphinic acid analogues proved to be rho1 GABA(C) receptor antagonists wi...

The brain sigma-1 receptors can bind neurosteroids and psychotropic drugs, including neuroleptics and cocaine and are implicated in schizophrenia, depression, and drug dependence. In this study, we found that sigma-1 receptors specifically target lipid storage sites (lipid droplets) on the endoplasmic reticulum by forming a distinct class of lipid microdomains. Both endogenously expressing sigm...

The metabotropic gamma-aminobutyric acid, type B (GABA(B)) receptors mediate the slow component of GABAergic transmission in the brain. Functional GABA(B) receptors are heterodimers of the two subunits GABA(B1) and GABA(B2), of which GABA(B1) exists in two main isoforms, GABA(B1a) and GABA(B1b). The significance of the structural heterogeneity of GABA(B) receptors, the mechanism leading to thei...

G protein-coupled receptors (GPCRs) are key players in cell communication and are encoded by the largest family in our genome. As such, GPCRs represent the main targets in drug development programs. Sequence analysis revealed several classes of GPCRs: the class A rhodopsin-like receptors represent the majority, the class B includes the secretin-like and adhesion GPCRs, the class F includes the ...

The SARS-CoV2 virus, which causes COVID-19, exerts its pathophysiological effect by intensively binding to the angiotensin-converting enzyme 2 receptor (ACE2) on host cells. By blocking ACE2 receptor, physiological functions of cell are inhibited, important for normal function various organs, and especially protection lungs. Therefore, number functionally active receptors is extremely body's re...

We examined the reproducibility of using the constant infusion paradigm for equilibrium measurement of D2/3 receptors using [ C](+)-propyl-hexahydro-naphtho-oxazin (PHNO) positron emission tomography (PET). Six subjects were scanned with a bolus plus constant infusion (Kbol 5 80 minutes) of [ C]-(+)-PHNO. Binding potential (BPND) was computed using the equilibrium approach and compared to a sim...