coprological analysis is still commonly employed to diagnose human fasciolosis despite the fact that this method is not utterly reliable. by far serologic methods in this case hold more validity and reliability. the purpose of the present study was to evaluate a 35-mer peptide covering a preliminary epitope of cathepsin l1, a new purified antigen of fasciola hepatica, by igg-elisa method for di...

It is well known that C-peptide fulfills an important function in the synthesis of insulin. After cleavage of proinsulin in the pancreatic b-cells, the 31-amino acid C-peptide is secreted into the portal circulation in equimolar concentrations with insulin. After its discovery in 1967 (1), it was believed that C-peptide might exert physiological effects similar to those of insulin. However, no ...

We tested the capacity of antibodies RB733, RB734, RB766, RB767, RB768, RB769, RB770, RB771, RB772 and RB773 to recognize by ELISA three different molecular forms human cardiac troponin T isoform 6 (cTnT): an N-terminal peptide (Nter-cTnT), full-length cTnT protein (FL-cTnT) I-T-C complex (ITC-complex). Our results show that RB734 specifically recognizes region as well alone ITC-complex. or in ...

BACKGROUND A recently halted clinical trial showed that intensive treatment of type 2 diabetes mellitus was associated with increased mortality. Given the phenotypic heterogeneity of diabetes, therapy targeted at insulin status may maximize benefits and minimize harm. METHODS In this longitudinal cohort study, we followed 503 patients with type 2 diabetes who were free of cardiovascular disea...

Patients with insulin resistance and early type 2 diabetes exhibit an increased propensity to develop a diffuse and extensive pattern of arteriosclerosis. Typically, these patients show elevated serum levels of the proinsulin cleavage product C-peptide and immunohistochemical data from our group revealed C-peptide deposition in early lesions of these individuals. Moreover, in vitro studies sugg...