Allergic reactions and contact dermatitis caused by the ingredients in toothpaste have been reported. 1 Some studies have documented allergic reactions to the flavorings used, especially cinnamic aldehyde.,3 Others have reported skin reactions to the preservatives, especially sodium benzoate,4-6 and to aluminum. Still others have shown contact dermatitis caused by sodium lauryl sulfate and prop...

AIMS To investigate the effect of RU486 (mifepristone) on emotional disorders in chronic restraint stress-induced rats and to explore the mechanisms of that phenomenon. METHODS For this purpose, 80 healthy male Sprague Dawley rats were randomly divided into four groups: the normal group (Con group, The Con group members received no treatment, eating and drinking freely), the chronic restraint...

PURPOSE The purpose of the present investigation was to evaluate the effectiveness of different vehicles on drug permeability and microstructure of intercellular or lipids in SC layer of skin. METHODS Pre-treated skin of rat using some vehicles including Labarac PG ,Transcutol P, tween 80, span 80 and propylene glycol (PG), were mounted on specialized design franz-diffusion cell was used to a...

School of Marilia, São Paulo, Brazil; Flow Citometry, and; Dermatology, Medical School of Marilia, Marilia, Brazil. Background: The prevalence of hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) is high and its in vitro diagnostic is a challenge. The basophil activation test with determination by flow cytometry (FC), of the expression rate of CD63 molecules has been much studie...

We were interested to read the article by Manini et al. (1), which confirmed previous observations that a severe ethylene glycol poisoning may lead to falsely elevated lactate levels (2). High lactate levels were indeed measured by enzymatic spectrophotometry (Integra analyzer) but excluded by a specific GC analysis. A linear correlation was nicely demonstrated between the serially determined b...

This study investigates crystallization, melting and glass transition of Li- Ca-12-hydroxystearate greases in relation to the pour point corresponding oils. The base oils for are mineral oil, polyalphaolefin, alkylated naphthalene, propylene glycol, trimellitate. For oil-based crystallization temperature Tc increases Tm decreases upon addition thickener. oil then is 3 K below does not properly ...

Single muscle fibers were exposed to solutions made hypertonic (approximately 460 milliosmols/kg water) by addition of either NaCl, glycerol, urea, acetamide, ethylene glycol, or propylene glycol. The changes in either the fiber twitch tension or the volume were measured. In the case of NaCl both fiber volume and twitch tension fall rapidly to 64 and 27% of the respective initial value. These t...

School of Marilia, São Paulo, Brazil; Flow Citometry, and; Dermatology, Medical School of Marilia, Marilia, Brazil. Background: The prevalence of hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) is high and its in vitro diagnostic is a challenge. The basophil activation test with determination by flow cytometry (FC), of the expression rate of CD63 molecules has been much studie...