The connections between excitatory and inhibitory synapses are significant for generation of busting activity in a pyramidal neuron model. We have suggested in previous studies that a reduced neuronal model of synaptically connected neurons could produce repetitive bursting activity. We have also suggested that the modification of the balance between inhibition and excitation by synaptic weight...

Episodic gene expression, with periods of high expression separated by periods of no expression, is a pervasive biological phenomenon. This bursty pattern of expression draws from a finite reservoir of expression machinery in a highly time variant way, i.e., requiring no resources most of the time but drawing heavily on them during short intense bursts, that intimately links expression bursting...

Using spectral analysis and in vivo single-unit recording in rats, the present study revealed a pronounced slow oscillation (SO) in the firing activity of about half the dopamine (DA) neurons recorded in the ventral tegmental area. DA neurons in this group tended to fire repetitive spike clusters, making them appear to be rhythmic bursting cells. However, only some of these burst-like events me...

Consolidation of fear extinction involves enhancement of N-methyl D aspartate (NMDA) receptor-dependent bursting in the infralimbic region (IL) of the medial prefrontal cortex (mPFC). Previous studies have shown that systemic blockade of metabotropic glutamate receptor type 5 (mGluR5) reduces bursting in the mPFC and mGluR5 agonists enhance NMDA receptor currents in vitro, suggesting that mGluR...

Dissolved oxygen (DO) concentrations were quantified near the sediment–water interface to evaluate DO transfer to sediments in a laboratory recirculating flume and open channel under varying fluid-flow conditions. DO concentration fluctuations were observed within the diffusive sublayer, as defined by the time-averaged DO concentration gradient near the sediment–water interface. Evaluation of t...

AIM To investigate whether in the prefrontal cortical (PFC) pyramidal cells, focal glutamate application to the apical dendrite induces bursting and whether the effect of glutamate involves activation of both NMDA and non-NMDA receptors. METHODS Pyramidal cells in layers V and VI of the PFC were visualized in rat brain slices using infrared videomicroscopy and recorded with whole-cell electro...

We considered a clustered network of bursting neurons described by the Huber-Braun model. In the upper level of the network we used the connectivity matrix of the cat cerebral cortex network, and in the lower level each cortex area (or cluster) is modelled as a small-world network. There are two different coupling strengths related to inter- and intracluster dynamics. Each bursting cycle is com...

This investigation examined the activity of a bilateral pair of motor neurons (B67) in the feeding system of Aplysia californica. In isolated ganglia, B67 firing exhibited a highly stereotyped bursting pattern that could be attributed to an underlying TTX-resistant driver potential (DP). Under control conditions, this bursting in the two B67 neurons was infrequent, irregular, and asynchronous. ...

Quantifying the mechanical forces produced by fluid flows within the ocean is critical to understanding the ocean's environmental phenomena. Such forces may have been instrumental in the origin of life by driving a primitive form of self-replication through fragmentation. Among the intense sources of hydrodynamic shear encountered in the ocean are breaking waves and the bursting bubbles produce...

Integrate-and-fire models of biological neurons combine differential equations with discrete spike events. In the simplest case, the reset of the neuronal voltage to its resting value is the only spike event. The response of such a model to constant input injection is limited to tonic spiking. We here study a generalized model in which two simple spike-induced currents are added. We show that t...