The skin is a tissue which is the most exposed to external factors. It is formed by numerous specialized cells and performs mainly protective functions. Due to its special properties such as: resistance, elasticity and semipermeability, it protects our body from mechanical injuries, infections, loss of physiological fluids as well as harmful radiation (1, 2). The human skin is formed of multi-l...

Objectives: Tigecycline is a new glycylcycline group antibiotic with broad-spectrum activity. In the present study we report on in vitro activity of tigecycline as well as the comparator antimicrobials linezolid and quinupristin/dalfopristin against methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA) strains isolated from burn wounds in Tr...

BACKGROUND The efficacy of Centella asiatica for incision and burn wounds are not fully understood. Here, we report the wound healing activities of sequential hexane, ethyl acetate, methanol, and water extracts of Centella asiatica in incision and partial-thickness burn wound models in rats. METHODS Male Sprague-Dawley rats weighing 250-300 g were randomly divided into incision and burn wound...

Traditionally, burn wounds are classified according to three different “degrees”, indicating the depth of the cellular destruction induced by the thermal energy transfer. Although this classification has the advantage of being relatively simple (and largely based on macroscopic indicators such as blisters, exudate, colour and sensitivity), it does not permit in all cases to make an accurate pre...

This is a study of 120 patients of either sex and all ages who had sustained deep burns of up to 40% of the total body surface area. Half the patients underwent early excision and skin autografting (i.e., within 4-7 days of sustaining burn injury) while the rest underwent delayed excision and skin autografting (i.e., within 1-4 weeks post-burn). Significant differences were found in favour of t...

Introduction: Burns are one of the most devastating of injuries, resulting in various consequences such as physical impairment as well as mental effects. At the Singapore General Hospital Burns Centre, a wide variety of burn injuries is seen annually. Our study looked at a unique group of patients; analysing the characteristics and outcome of burn wounds among conscripted Singaporean soldiers a...

The use of honey in the treatment of burn wounds is discussed and an attempt is made to assess honey's current status as a burn wound dressing. Various kinds of honey are considered, as also the history of its use for this purpose since ancient times. The scientific reasons for honey's appropriateness in burns treatment are reviewed and an account is provided of the main benefits of such treatm...

Clinical examination alone is not always sufficient to determine which burn wounds will heal spontaneously and which will require surgical intervention for optimal outcome. We present a review of optical modalities currently in clinical use and under development to assist burn surgeons in assessing burn wound severity, including conventional histology/light microscopy, laser Doppler imaging, in...

This study addressed self-blame and adaptation by using data collected from 49 patients hospitalized for the treatment of acute burn wounds. Nurses and physical therapists rated patients' compliance with the therapeutic activities essential for proper healing, and they rated pain behavior. After controlling for burn severity and time since admission, regression analyses showed that behavioral s...

Thermal injury destroys the physical skin barrier that normally prevents invasion of microorganisms. This and concomitant depression of local and systemic host cellular and humoral immune responses are important factors that contribute to colonization and infection of the burn wound. One of the most common burn wound pathogens is Staphylococcus aureus. Staphylococcus aureus is both a human comm...