A therapeutic endpoint is a very important tool to evaluate response in clinical trials. In 2005, a consensus statement identified two late endpoints of disease activity in pemphigus: complete remission off therapy and complete remission on therapy, both definitions applying to patients without lesions for at least 2 months. The same period of time was considered for partial remission off/on th...

purpose : cutaneous anthrax of the eyelid is a rare condition in clinical practice, but should be considered in the differential diagnosis of preseptal and orbital cellulitis. here we report a case of palpebral anthrax. case report : a 5-year-old girl with anthrax infection of the right upper eyelid is presented. her eyelid showed an edematous, necrotic, and partially bullous lesion. following ...

BACKGROUND There has been a worldwide resurgence of bedbug infestations. Bites by these insects may cause mild or severe cutaneous reactions, and anaphylaxis has been reported. Little is known about the most severe cutaneous reactions, termed bullous or complex reactions. OBJECTIVE To study the time course and histopathologic findings of complex (bullous) cutaneous reactions to bedbugs in ord...

Sir, Pyoderma gangrenosum (PG) is a sterile, pustular, ulcerative process of unknown cause (1). It is frequently associated with various systemic diseases, including inflammatory bowel disease, arthritis, monoclonal gammopathy, malignant disease (2) and, rarely, Behçet’s disease (3). Four clinical and histological variants have been recognized: ulcerative, pustular, bullous and vegetative. Vege...

Impetigo is an endemic bacterial skin infection most commonly associated with the pediatric population; it is seen in more than an estimated 162 million children between the ages of 2 and 5 years old. Geographically, this infection is mostly found in tropical areas around the globe. Impetigo has the largest increase in incidence rate, as compared to other various skin infections seen in childre...

PURPOSE Expression of cellular adhesion molecules is altered in bullous keratopathy. The hypothesis that epithelial alterations in bullous keratopathy compromise the surface of the cornea and its glycocalyx was tested. METHODS Studies were performed on eight cases each of pseudophakic bullous keratopathy and healthy corneas. The number of epithelial cell layers was determined with a stereolog...

Introduction: Oral lichen planus is a T cell mediated autoimmune disease which often affects middle-aged adults. Amongst the reticular, atrophic and erosive types, bullous form of lichen planus is rarely observed. Case Report: A case of 60-year-old male complaining of discomfort in lower front gingiva with occasional fluid filled vesicles in same area and buccal mucosa. Based on clinical and hi...

Linear IgA disease is an autoimmune subepidermal bullous disease in which linear IgA deposits are found at the basement membrane zone. It is classically idiopathic but may be drug induced. We report on a patient with drug induced linear IgA disease who exhibited certain unusual and interesting clinical features including isomorphic Koebner response, annular blister of the nipples and local insu...

High-dose intravenous immunoglobulin (hdIVIg) is being used increasingly for dermatological indications. Its mode of action is via a number of proposed mechanisms and it is not associated with the many side-effects of steroids and other immunosuppressive agents. The evidence for using hdIVIg in the treatment of autoimmune bullous disorders is based on uncontrolled trials and case reports. Howev...

OBJECTIVE To investigate the safety and efficacy of oral methylprednisolone combined with azathioprine sodium or mycophenolate mofetil for the treatment of bullous pemphigoid. DESIGN A prospective, multicenter, randomized, nonblinded clinical trial to compare 2 parallel groups of patients with bullous pemphigoid undergoing different treatments. SETTING Thirteen departments of dermatology in...