The bromodomain-containing chromatin-modifying factor BRD4 is an inherited susceptibility gene for breast cancer progression and metastasis, but its functionality in these settings has yet to be explored. Here we show that deletion of either of the BRD4 bromodomains had modest effects on the metastatic suppression ability of BRD4. In contrast, expression of the natural short isoform of BRD4 tha...

A 36 yr-old man of Israeli descent with a history of childhood splenectomy for severe thrombocytopenia and a family history of autoimmune lymphoproliferative syndrome (ALPS), presented with severe immune thrombocytopenic purpura refractory to standard therapy. He was found to possess a heterozygous mutation in the Fas gene (also termed TNFRSF6, CD95, Apo-1) affecting the donor splice site of in...

We present a preliminary investigation on the usefulness of prosodic boundaries for unsupervised term discovery (UTD). Studies in language acquisition show that infants use prosodic boundaries to segment continuous speech into word-like units. We evaluate whether such a strategy could also help UTD algorithms. Running a previously published UTD algorithm (MODIS) on a corpus of prosodically anno...

We report the first description of a rare catalase-negative strain of Staphylococcus aureus in Chile. This new variant was isolated from blood and synovial tissue samples of a pediatric patient. Sequencing analysis revealed that this catalase-negative strain is related to ST10 strain, which has earlier been described in relation to S. aureus carriers. Interestingly, sequence analysis of the cat...

The dynamics of elastocapillary thinning in high molecular weight polymer solutions are reexamined using high-speed digital video microscopy. At long times, the evolution of the viscoelastic thread deviates from self-similar exponential decay and the competition of elastic, capillary, and inertial forces leads to the formation of a periodic array of beads connected by axially uniform ligaments....

The DDK complex is a conserved kinase complex, consisting of a catalytic subunit, Hsk1 (Cdc7), and its regulatory subunit Dfp1 (Dbf4). This kinase is essential for DNA replication. In this work, we show that dfp1-r35, which truncates the Dfp1 C-terminus zinc finger, causes severe meiotic defects, including reduced spore viability, reduced formation of programmed double strand breaks, altered ex...

We investigate the possibility that, in a combined theory of quantum mechanics and gravity, de Sitter space is described by finitely many states. The notion of observer complementarity, which states that each observer has complete but complementary information, implies that, for a single observer, the complete Hilbert space describes one side of the horizon. Observer complementarity is implemen...

A distinguishing feature of dialogue is that contributions can be fragmentary or incomplete. Such incomplete utterances may be later completed by another interlocutor. These cross-person compound contributions (CCs) have been hypothesised to be more likely in predictable contexts but the contributions of different sources of predictability has not been systematically investigated. In this paper...