Olfactory dysfunction is common in Parkinson's disease and is an early symptom, but its pathogenesis remains poorly understood. Hindering progress in our mechanistic understanding of olfactory dysfunction in Parkinson's disease is the paucity of literature about the human olfactory bulb, both from normal and Parkinson's disease cases. Qualitatively it is well established that the neat arrangeme...

Since the invention of light bulb by T [...]

BACKGROUND Irrigating ears to remove wax is a time-consuming procedure in UK primary care. In many other countries bulb syringes are used for self-clearance of earwax but evidence of their effectiveness is lacking. AIM To compare the effectiveness of self-treatment bulb syringes with routine care. DESIGN OF STUDY Open, randomised, controlled trial. SETTING Seven practices in Hampshire, UK...

Although four different primary olfactory pathways have been described in tetrapod vertebrates, polymorphic olfactory sensory neurons comingle in the olfactory epithelium and project axons into separate bulbar regions in teleost fish. However, spatially segregated neurons may exist in the peripheral olfactory organ of lampreys, extant representatives of ancestral jawless vertebrates. In lamprey...

Hyperhomocysteinemia has been shown to be associated with neurodegenerative diseases; however, lesions or histological changes and mechanisms underlying homocysteine-induced injury in olfactory bulb neurons remain unclear. In this study, hyperhomocysteinemia was induced in apolipoprotein E-deficient mice with 1.7% methionine. Pathological changes in the olfactory bulb were observed through hema...

Eighteen hybrid onion and 23 open-pollinated (OP) varieties were tested in southern New Mexico for plant characteristics, disease resistance, and bulb yield in order to determine if hybrid varieties outperformed OP varieties. Varieties were shortto intermediate-day in their bulbing response and were planted in the fall seasons of 1997 and 1998 and harvested the following May or June. Varieties ...

This paper describes how we design a lighting control system including hardware and software. Hardware includes Dimmer with relays Bulb light sensing circuit, control circuit, and 8255 expanding I/O circuit, PC, and bulb. Sensing circuit uses photo-resistance component to sense the environmental light and then transmit the signal of the lightness to the computer through an 8-bit A/D converter 0...

Microglia, the innate immune cells of the brain, engulf and eliminate cellular debris during brain injury and disease. Recent observations have extended their roles to the healthy brain, but the functional impact of activated microglia on neural plasticity has so far been elusive. To explore this issue, we investigated the role of microglia in the function of the adult olfactory bulb network in...

Leptin, the product of the Ob(Lep) gene, is a peptide hormone that plays a major role in maintaining the balance between food intake and energy expenditure. In the brain, leptin receptors are expressed by hypothalamic cells but also in the olfactory bulb, the first central structure coding for odors, suggesting a precise function of this hormone in odor-evoked activities. Although olfaction pla...

A glutathione S-transferase (GST, EC 2.5.1.18) inhibitor was isolated from the onion bulb by fractionation and purification using Sep-pak Vac C18 column, TLC and HPLC. Five partially purified onion bulb GSTs (GSTa and GSTb as minor GSTs, and GSTc, GSTd and GSTe as dominant GSTs) separated by DEAE column were used to detect the inhibitory substance in onion bulb extract. Among the three fraction...