The ciliary transition zone (TZ) is a complex structure found at the cilia base. Defects in TZ assembly are associated with human ciliopathies. In most eukaryotes, three protein complexes (CEP290, NPHP, and MKS) cooperate to build the TZ. We show that in Drosophila melanogaster, mild TZ defects are observed in the absence of MKS components. In contrast, Cby and Azi1 cooperate to build the TZ by...

BACKGROUND The different effects of LDL-C levels and statins therapy on coronary atherosclerotic plaque between Western and Asian remain to be settled. METHODS PubMed, EMBASE, and Cochrane databases were searched from Jan. 2000 to Sep. 2014 for randomized controlled or blinded end-points trials assessing the effects of LDL-C lowering therapy on regression of coronary atherosclerotic plaque (C...

BACKGROUND Positive arterial remodeling and thin fibrous cap are characteristics of rupture-prone or vulnerable plaque. The natural course of the fibrous cap thickness and the relationship between serial arterial remodeling and changes in fibrous cap thickness are unknown. Therefore, the purpose of this study was to evaluate the relationship between changes in fibrous cap thickness and arterial...

Although the mechanism of microtubule dynamic instability is thought to involve the hydrolysis of tubulin-bound GTP, the mechanism of GTP hydrolysis and the basis of microtubule stability are controversial. Video microscopy of individual microtubules and dilution protocols were used to examine the size and lifetime of the stabilizing cap. Purified porcine brain tubulin (7-23 microM) was assembl...

As thousands of individuals surf the internet daily, every image on every web page is saved automatically to their computer's cache, absent user direction. Sections 2252(a)(2) and 2252(a)(4)(B) of Title 18 of the U.S. Code criminalize knowing possession and knowing receipt of child pornography images. For the defendant who intentionally saves illicit images to his computer, the cache simply ver...

The measure or determination of uncertainty a system is known as entropy. After the rich idea entropy, it gains attraction and interest in graph theory, due to its applications applied mathematical chemistry. First time entropy was used 1955, know structural information chemical networks graphs. In chemistry, structures are build-up atoms/vertices bonds/edges. Carbon nanotubes also very famous ...

$EVWUDFW Relying fully on manual effort in generating metadata is not the way to go: we need automation of this process, as much as possible, without losing the “quality” of the metadata. In this paper we report on our experiences with automatic metadata generation. We briefly outline the first version of our framework for automatic metadata generation and then report on some lessons we learned...

BACKGROUND Information is limited on risk factors for community-acquired pneumonia (CAP) in free-living populations. We examined the associations of age, smoking status, body mass index (BMI), weight change during adulthood, physical activity, and alcohol intake with risk of CAP among men and women. METHODS The study population included 26,429 men aged 44 to 79 years from the Health Professio...