BMY 25282 and BMY 25067, analogues of mitomycin C (MMC), were synthesized in an attempt to increase the therapeutic potential of the parent drug. The present studies were undertaken to determine if the cytotoxicity of MMC or its analogues is affected by cellular glutathione (GSH) and/or GSH transferase (GST) levels by using sensitive (P388/S) and multidrug resistant (P388/R-84) mouse leukemia c...

Brain-storm optimization (BSO), which is a population-based algorithm, exhibits poor search performance, premature convergence, and high probability of falling into local optima. To address these problems, we developed the adaptive mechanism-based BSO (ABSO) algorithm based on chaotic in this study. The adjustment space using method an self-scaling mechanism balances global development performa...

Objectives . This study aims to obtain the amino acid derivatives of chlorophyll a and bacteriochlorophyll for targeted delivery pigments tumor foci. will increase biocompatibility and, as result, reduce toxic side effects. In addition photodynamic efficiency, an additional cytotoxic effect is expected obtained conjugates photosensitizers (PSs) with acids. owing participation latter in intracel...

Purpose: The purpose of this study was to identify prognostic factors associated with the successful outcome endometrial cancer (EC) in women aged ≤40 years. Methods: This a retrospective cohort study. medical records all ≤ 40 years EC diagnosed on curettage between 1995 and 2020 were reviewed. Patients who underwent hysterectomy whose final histopathological evaluation made our hospital, or ev...

The role of glutathione (GSH) in tumor cell resistance to alkylating agents and platinum compounds is suggested by a body of laboratory and clinical studies. The rate-limiting enzyme in GSH synthesis is y-glutamylcysteine synthetase (y-GCS), the expression of which is proportional both to GSH content and to the level of resistance in ovarian cancer cell lines. The role of this enzyme in regulat...

Improvement of the treatment results in patients with endometrial carcinoma has been achieved by a multidisciplinary approach including surgery, chemotherapy and radiotherapy, similar to the case for many other carcinomas. Although total hysterectomy/bilateral salpingo-oophorectomy (TH/BSO), pelvic and para-aortic lymphadenectomy and peritoneal cytology are often required, cases with early carc...

Several recent studies have shown that certain forms of genetic or acquired hypertension are associated with oxidative stress and that animals with those types of hypertension respond favorably to antioxidant therapy. We hypothesize that oxidative stress may cause hypertension via (among other mechanisms) enhanced oxidation and inactivation of nitric oxide (NO). To test this hypothesis, Sprague...

Cellular glutathione (GSH) levels were found to be 7-fold higher in a human lung adenocarcinoma cell line (A549) than in a normal human lung fibroblast line (CCL-210). Differential modulation of cellular GSH was explored in these cell lines by (a) stimulation of GSH synthesis by oxothiazolidine-4-carboxylate (OTZ) and (b) inhibition of GSH synthesis by buthionine sulfoximine (BSO). In the tumor...