Mapping between local and global coordinates is an important issue in finite element method, as all calculations are performed in local coordinates. The concern arises when subparametric are used, in which the shape functions of the field variable and the geometry of the element are not the same. This is particularly the case for * C elements in which the extra degrees of freedoms added to the ...

The aim of this study is to examine the effects two earthquakes in Kahramanmaraş/Türkiye on February 06, 2023 Borsa Istanbul (BIST) stock markets a sectoral basis. In context, it investigated whether there statistically significant difference between returns before and after earthquake. study, 18 BIST index are divided into sub-samples as pre-earthquake post-earthquake analyzed by event method....

Biologics mainly monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) as new therapeutics are becoming increasingly important biotherapeutics. This review is intended to provide an overall comparison between small molecules (SMs) and biologics or large molecules (LMs) concerning drug metabolism and pharmacokinetic (DMPK) or associated with absorption, distribution, metabolism and el...

Starting with a novel definition of divided differences, this essay derives and discusses the basic properties of, and facts about, (univariate) divided differences. “It belongs to the most beautiful I have been able to do.”[Newton 1676]

In the prophetic words of Abraham Lincoln in addressing the antebellum Nation, " A house divided against itself cannot stand. " As physicians, we too live in a house divided. We factionalize along lines of specialty, practice size, practice location, ethnicity, etc. As emergency physicians, we are among the most egregious in splintering the House of Medicine. We have subdivided our small young ...