In antimalarial research there are no standard procedures to determine the toxicity of a drug candidate. Among alternatives available, in vitro cytotoxicity assays most widely used predict toxic effects future therapeutic products. They have advantage over vivo assays, that they offer possibility restrain number experimental variables. The objective present study was compare cytotoxic methods b...

BACKGROUND Semecarpus parvifolia Thw is used as an ingredient of poly herbal decoctions to treat cancer in traditional medicine. The present study aims to investigate the antiproliferative activity on HEp 2 cells by the water extract of S. parvifolia leaves and to evaluate potential mechanisms. METHODS The plant extract was exposed to S. parvifolia for 24 hours and antiproliferative activity ...

The current study evaluated the general toxicity, antioxidant, antimicrobial, and cytotoxic activity of extracts obtained from the rhizomes of Eremostachys azerbaijanica (Labiatae) as well as analyzed the potent extracts using GC-MS. Extracts of E. azerbaijanica in n-hexane, dichloromethane (DCM) and methanol (MeOH) were prepared using a Soxhlet apparatus. The antioxidant activity of the extrac...

the present study was designed to assess the cytotoxicity, anti-inflammatory and analgesic properties of methanol extract of woodfordia fruticosa flowers. cytotoxic activity of methanol extract of woodfordia fruticosa flowers was tested using artemia salina (brine shrimp) bioassay. two doses (400 and 600 mg/kg) were evaluated for the anti-inflammatory activity against the carrageenan, histamine...

numerous studies have been focused on natural anticarcinogenic agents. many antioxidants have been identified as anticarcinogens. antimutagens have also been proposed as cancer chemopreventive agents. the use of natural products as anticancer has a long history that began with traditional medicine. the aim of this study was to evaluate cytotoxicity and antioxidant activity of twenty-three plant...

This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds' structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in tBOH- or LPS-stimulated J774.A1 macrophages. All co...

Secondary compounds in fruit mediate interactions with natural enemies and seed dispersers, influencing plant survival and species distributions. The functions of secondary metabolites in plant defenses have been well-studied in green tissues, but not in reproductive structures of plants. In this study, the distribution of toxicity within plants was quantified and its influence on seed survival...