نتایج جستجو برای: breast tissues

تعداد نتایج: 433592  

Journal: :Pathobiology : journal of immunopathology, molecular and cellular biology 2008
Ying Jiang Dandan Tong Ge Lou Ying Zhang Jingshu Geng

BACKGROUND Runt-related transcription factor 3 (RUNX3) is a novel tumor suppressor gene that is frequently silenced by promoter hypermethylation in gastric cancer. In this study, we aimed to analyze the methylation status of the RUNX3 promoter in breast cancer and to evaluate the relationship between RUNX3 expression and breast carcinogenesis and prognosis. METHODS RT-PCR and Western blot wer...

Journal: :Genes, chromosomes & cancer 2008
Anuradha Poonepalli Birendranath Banerjee Kalpana Ramnarayanan Nallasivam Palanisamy Thomas Choudary Putti M Prakash Hande

A study was undertaken to correlate telomere dysfunction and genomic instability with the histopathological grades and the estrogen and progesterone receptor status in breast cancer. Sixty-one archived breast tissues (38 cancer tissues and 23 paired normal tissues) were used in the study. The breast tumor tissues showed significantly shorter telomeres (7.7 kb) compared with the paired adjacent ...

2004
T Wu

Mammography is currently the most effective breast cancer screening technique. It has been shown by clinical studies that mammography has reduced the mortality by 30~50%. However, mammography is not a perfect technique in that about 30% of breast cancers are missed. A major limit to the sensitivity of conventional mammography is the superimposition of the breast tissue. A mammogram is a two-dim...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2001
A Ghadersohi A K Sood

PURPOSE There is a need to identify novel breast tumor-associated molecules with a potential as diagnostic/prognostic markers of breast cancer as well as targets of vaccine and drug discovery against this cancer. EXPERIMENTAL DESIGN We used a combination of digital differential display and reverse transcription-PCR (RT-PCR) methods to identify breast tumor-associated cDNAs. RESULTS It was f...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2012
Zhaolei Zeng Huanxin Lin Xiaohui Zhao Guanglin Liu Xi Wang Ruihua Xu Kun Chen Jun Li Libing Song

PURPOSE Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in various biologic processes. The clinical significance and biologic role of GOLPH3 in breast cancer, however, remains unknown. EXPERIMENTAL DESIGN Expression of GOLPH3 in normal breast cells, breast cancer cells, and 6-paired breast cancer and adjacent noncancerous tissues were quantified using real-time PCR and Wester...

2007
Ki-Tae Hwang Wonshik Han Ji-Yeon Bae Sung Eun Hwang Hyuk Jai Shin Jeong Eon Lee Sung-Won Kim Hyun Jung Min Dong-Young Noh

The RUNX3 gene is regarded as a tumor suppressor gene in many human solid tumors, and its inactivation is believed to be related with solid tumor carcinogenesis. As little information is available about the role of the RUNX3 gene in breast cancer, we investigated the relationship between the RUNX3 gene and breast cancer. We performed reverse transcriptase-polymerases chain reaction (RT-PCR), me...

Journal: :Journal of the National Cancer Institute 2008
Eva-Maria Boneberg Daniel F Legler Hans-Jörg Senn Gregor Fürstenberger

Recently reported results of a phase 2 study combining the aromatase inactivator exemestane with the cyclooxygenase-2 (COX-2) inhibitor celecoxib for the treatment of breast cancer showed that patients receiving the combined treatment had response rates and clinical benefit rates that were similar to those of the group receiving exemestane only (1). The rationale for using a COX-2 inhibitor for...

Journal: :basic and clinical cancer research 0
nosratollah zarghami department of clinical biochemistry and ria, drug applied research center, tabriz university of medical sciences, tabriz, iran mohammad rahmati department of clinical biochemistry and ria, drug applied research center, tabriz university of medical sciences, tabriz, iran abbas mohajeri department of clinical biochemistry and ria, drug applied research center, tabriz university of medical sciences, tabriz, iran mohammad pourhassan department of clinical biochemistry and ria, drug applied research center, tabriz university of medical sciences, tabriz, iran jahanbakhsh asadi department of clinical biochemistry, faculty of medicine, gholestan university of medical sciences, ghorghan, iran

background: the present study was performed to investigate the effects of trace elements particularity se, zn and cu on tumor genesis in breast cancer. methods: the inhibitory effect of se, zn and cu, on telomerase activity was analyzed in human breast tumor tissues and breast cancer (t47d) cells. tissue specimens from 24 women with benign breast disease and 32 women with breast cancer specimen...

Introdution: Today, the Advantages of radiation therapy by charged particles is indicated for the treatment of cancerous. During the passing of proton beam in the body tissues, secondary particles produce, which penetrate to the body healthy tissues and cause damage. The aim of this research was calculating the Spread out Bragg Peak for covering the breast cancer and investigating arrived dose ...

2017
Annelie Abrahamsson Anna Rzepecka Charlotta Dabrosin

Metabolic reprogramming is a hallmark of cancer. Nutrient availability in the tissue microenvironment determines cellular events and may play a role in breast carcinogenesis. High mammographic density is an independent risk factor for breast cancer. Whether nutrient availability differs in normal breast tissues with various densities is unknown. Therefore we investigated whether breast tissues ...

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