PURPOSE To determine the impact of radiation on neural stem cells and examine the feasibility of neural stem cell sparing using volumetric modulated arc therapy (VMAT) for whole brain irradiation. METHODS Murine neural stem cells were harvested from the sub-ventricular zone (SVZ), cultured and assessed for radio-sensitivity and differentiation potential in response to radiation (0-6Gy). Clono...

background: differentiation ofmesenchymal stem cells (mscs) to hepatocyte-like cells could be associated with development of liver function factors. the impact of differentiation-dependent changes on dna integrity is not well understood. in this study, hepatocytes and their progenitor stem cells were treated with aflatoxin b1 (afb1) and amplification of selected genes linked to dna damage was e...

to study the effect of urea application in safflower (carthamus tinctorius) and determination of effective traits on its yield, a factorial experiment based on randomized complete block design in three replications was conducted in tabriz, iran, during 2012. studied factors were urea rate levels as 100, 150 and 200 kg/ha and urea application times 100% in sowing time, 50% sowing time + 50% stem...

Front cover: Cover image: Distribution of HOPX and BLBP in cerebellum brain stem from a 21 wpc human fetal brain. is most prevalent corpus pontobulbare (CPB). seem to occupy different regions this cellular aggregate dominated by strong immunoreactivity. also scattered the present dentate nucleus as well blood vessel walls. In cerebellar cortex mostly confi ned Purkinje cell layer. Also note rea...

When brain injury is refractory to aggressive management and is considered nonsurvivable, with loss of consciousness and brain stem reflexes, a brain death protocol may be initiated to determine death according to neurological criteria. Clinical evaluation typically entails 2 consecutive formal neurological examinations to document total loss of consciousness and absence of brain stem reflexes ...

Drosophila neuroblasts, the stem cells of the developing fly brain, have emerged as a key model system for neural stem cell biology and have provided key insights into the mechanisms underlying asymmetric cell division and tumor formation. More recently, they have also been used to understand how neural progenitors can generate different neuronal subtypes over time, how their cell cycle entry a...

All multicellular organisms undergo a decline in tissue and organ function as they age. An attractive theory is that a loss in stem cell number and/or activity over time causes this decline. In accordance with this theory, aging phenotypes have been described for stem cells of multiple tissues, including those of the hematopoietic system, intestine, muscle, brain, skin and germline. Here, we di...