EditorialThe rise in obesity and diabetes in various countries have reached epidemic proportions [1] with the inability of the brain to regulate body weight and energy balance in the early part of life and related to neurodegenerative disease in these countries. Neurons in the brain become sensitive to Western diets with alterations in neurons that lead to brain circuitry disorders or feeding s...

The kinetic assembly of protein complexes containing the VDAC (voltage dependent anion channel) follows a quite different pattern in bovine brain in comparison with rat neuronal cells. In order to investigate if the differential expression of VDACs between chicken brain when compared with bovine and rat brain mitochondria was linked to a differential VDAC interactome, we utilized BN-PAGE of mit...

To study neurons or glia-specific mitochondria one needs to isolate these organelles from primary neuronal or astrocytic cell culture. This work provides novel method for isolation of functional and morphologically intact mitochondria from neurons and astrocytes in cell cultures. In the first step, mitochondria are released from cells by disruption of cell membranes using a nitrogen cavitation ...

TDP-43 protein is found deposited as inclusions in the amyotrophic lateral sclerosis (ALS) patient's brain. The mechanism of neuron death ALS not fully deciphered but several toxicity mechanisms such mis-regulation autophagy, mitochondrial impairment and generation oxidative stress etc., have been implicated. A predominantly nuclear protein, Cyclin C, can regulate response via transcription gen...

Natural products isolated from plant sources are well known for their pharmacological potential in diversity of disease treatments such as inflammatory or cancer conditions. Mango (Mangifera indica L.) and Juglans regia are thought to be rich of functional phytochemicals. To elucidate the anticancer activity of Juglans regia (JR) and Mangifera indica L (MI) aqueous extract were investigated on ...

Natural products isolated from plant sources are well known for their pharmacological potential in diversity of disease treatments such as inflammatory or cancer conditions. Mango (Mangifera indica L.) and Juglans regia are thought to be rich of functional phytochemicals. To elucidate the anticancer activity of Juglans regia (JR) and Mangifera indica L (MI) aqueous extract were investigated on ...