Background/introduction Cavitation-mediated therapies for the brain, such as ultrasound-induced Blood-Brain barrier opening and sonothrombolysis for the treatment of stroke, are being increasingly investigated. Robust methods for monitoring and controlling cavitation are necessary for safe translation of these techniques into clinical practice. This talk will review our work detecting and mappi...

Solving problems often requires seeing new connections between concepts or events that seemed unrelated at first. Innovative solutions of this kind depend on analogical reasoning, a relational reasoning process that involves mapping similarities between concepts. Brain-based evidence has implicated the frontal pole of the brain as important for analogical mapping. Separately, cognitive research...

This article introduces the history and the long-term goals of the Korea Brain Initiative, which is centered on deciphering the brain functions and mechanisms that mediate the integration and control of brain functions that underlie decision-making. The goal of this initiative is the mapping of a functional connectome with searchable, multi-dimensional, and information-integrated features. The ...

Direct cortical stimulation (DCS) is considered the gold-standard for functional cortical mapping during awake surgery for brain tumor resection. DCS is performed by stimulating one local cortical area at a time. We present a feasibility study using an intra-operative technique aimed at improving our ability to map brain functions which rely on activity in distributed cortical regions. Followin...

A methodology for spatial normalization of image data is presented. This methodology is based on a map between homologous features of an individual brain and the target brain, which is used to drive a three-dimensional elastic warping transformation. Functional or structural information present in the original, nonnormalized images is preserved during this transformation. In particular, informa...

www.sciencemag.org SCIENCE VOL 329 16 JULY 2010 249 COVER A seedling carpet dominated by Dipteryx oleifera (almendro) in the forest understory of Barro Colorado Island, Panama. Seedlings here have a lower probability of surviving when surrounded by neighbors of their own species. However, rare species suffer more from the presence of like neighbors than do common species, suggesting a mechanism...

We review recent developments in brain mapping and computational anatomy that have greatly expanded our ability to analyze brain structure and function. The enormous diversity of brain maps and imaging methods has spurred the development of population-based digital brain atlases. These atlases store information on how the brain varies across age and gender, across time, in health and disease, a...

The development of tools to construct and investigate probabilistic maps of the adult human brain from magnetic resonance imaging (MRI) has led to advances in both basic neuroscience and clinical diagnosis. These tools are increasingly being applied to brain development in adolescence and childhood, and even to neonatal and premature neonatal imaging. Even earlier in development, parallel advan...