Recent studies have shown that renal ischemia-reperfusion injury can detrimental effects on distant organs such as the brain, liver and lungs. In this study, we aimed to investigate of pancreatic functions.
 Materials Methods. Twenty four male adult Wistar rats were divided into groups. Sham control group animals not given any medications. Animals in groups 3 4 treated with epidural bupiva...

The state of water in cerebral ischemia was studied by using the proton nuclear magnetic resonance (1H-NMR) method. Cerebral ischemia was induced experimentally in Mongolian gerbils by unilateral ligation of the common carotid artery. Longitudinal (T1) and transverse (T2) relaxation times of the ischemic brain were measured with a pulse FT-NMR spectrometer and the water content was determined b...

Peripheral vascular disease is circulation disorders that affect blood vessels outside of the heart and brain. Smoking tobacco main culprit for PVD. Management atherosclerosis plays an important role in adult medical care. The objective present study was to determine cardiovascular comorbidities associated with different stages peripheral current use pharmacological risk reducing therapy among ...

Lactate is an intriguing molecule with emerging physiological roles in the brain. It has beneficial effects animal models of acute brain injuries and traumatic injury or subarachnoid hemorrhage patients. However, mechanism by which lactate provides protection unclear. While there evidence a metabolic effect providing energy to deprived neurons, it can also activate hydroxycarboxylic acid recept...

Two hours of transient focal brain ischemia causes acute neuronal death in the striatal core region and a somewhat more delayed type of neuronal death in neocortex. The objective of the current study was to investigate protein aggregation and neuronal death after focal brain ischemia in rats. Brain ischemia was induced by 2 hours of middle cerebral artery occlusion. Protein aggregation was anal...

PURPOSE To examine the possibility that hyperventilation, commonly used to prevent or treat increased intracranial pressure in patients with acute brain lesions, may induce significant cerebral ischemia. METHODS Local cerebral blood flow and vascular reactivity were measured before and after hyperventilation using xenon-enhanced CT in 12 patients with acute brain lesions. RESULTS Five patie...

Hypothermia protects tissue function in ischemia. This study determined if selective brain cooling inhibits cerebral cortical lactate accumulation and thus accounts for imporved neurologic outcome after complete cerebral ischemia in dogs. The brain was selectively cooled (hippocampal temperature 33 degrees C) by nasal lavage with water at 5 degrees C. Control dogs received nasal lavage with wat...

The general failure of neuroprotectants in clinical trials of ischemic stroke points to the possibility of a fundamental blind spot in the current conception of ischemic brain injury, the "ischemic cascade". This is the second in a series of four papers whose purpose is to work towards a revision of the concept of brain ischemia by applying network concepts to develop a bistable model of brain ...

BACKGROUND Overproduction of free radical species has been shown to occur in brain tissues after ischemia-reperfusion injury. However, most of free radical scavengers known to antagonize oxidative damage (e.g. superoxide dismutase, catalase), are unable to protect against ischemia-reperfusion brain injury when given in vivo, an effect mainly due to their difficulty to gain access to brain tissu...

Transient and permanent focal cerebral ischemia results in a series of typical pathophysiologic events. These consequences evolve in time and space and are not limited to the lesion itself, but they can be observed in perilesional (penumbra) and widespread ipsi- and sometimes contralateral remote areas (diaschisis). The extent of these areas is variable depending on factors such as the type of ...