A pooling design can be used as a powerful strategy to compensate for limited amounts of samples or high biological variation. In this paper, we perform a comparative study to model and quantify the effects of virtual pooling on the performance of the widely applied classifiers, support vector machines (SVMs), random forest (RF), k-nearest neighbors (k-NN), penalized logistic regression (PLR), ...

Scientists who use animals in research must justify the number of animals to be used, and committees that review proposals to use animals in research must review this justification to ensure the appropriateness of the number of animals to be used. This article discusses when the number of animals to be used can best be estimated from previous experience and when a simple power and sample size c...

Transcriptomics meta-analysis aims at re-using existing data to derive novel biological hypotheses, and is motivated by the public availability of a large number of independent studies. Current methods are based on breaking down studies into multiple comparisons between phenotypes (e.g. disease vs. healthy), based on the studies' experimental designs, followed by computing the overlap between t...

This paper re-visits the Bayesian approach to test its efficacy in optimally designing the classical (s, Q) inventory model. A heuristic search of the unstructured (s, Q) decision space finds that one can indeed make a decent start by the Bayesian approach—and keep total cost nearly optimally low throughout.

Equivalence Classes of Circuit Mutants for Experimental Design Debabrata Ghosh Franc Brglez CBL (Collaborative Benchmarking Lab), Dept. of Computer Science, Box 7550 NC State University, Raleigh, NC 27695, USA http://www.cbl.ncsu.edu/ Abstract { Experimental Design, as de ned in science and manufacturing, relies on data sets that belong to well-de ned equivalence classes. This paper introduces ...

This paper presents the micro-finishing of bevel gears by electrochemical-mechanical finishing (ECMF) process under different experimental conditions of current, rotating speed of workpiece and electrolyte concentration. These different experimental conditions are planned on the basis of box behnken design (BBD) design of experiments (DOE) technique of response surface methodology (RSM). An emp...

This paper presents a wireless diaphragm actuator and focuses on a lumped parameter grey-box model capable of simulating actuation displacement. Here, modelling aims to provide further insight into this smart material actuator and help facilitate design into new implantable applications. Model parameters were calibrated to a prototype actuator using experimental data and a genetic algorithm opt...