Background/Aim: The purpose of this study was to investigate whether bone morphogenetic protein (BMP)-4 expression differs according the presence calcification in papillary thyroid carcinoma and if BMP-4 are associated with metastasis carcinoma.Methods: We performed using paraffin-embedded tissues 55 patients who underwent thyroidectomy Kosin University Gospel Hospital. Of those cases, 36 were ...

Signal transduction by the Smad pathway elicits critical biological responses to many extracellular polypeptide factors, including TGFβ and bone morphogenetic protein. Regulation of Smad signaling imparts several cytoplasmic and nuclear mechanisms, some of which entail protein phosphorylation. Previous work established a protein complex between Smad4 and the scaffolding protein LKB1-interacting...

Source and Description of Probe. A 2.2-kb human cDNA clone for bone morphogenetic protein 5 (BMP5) was excised from the clone U2-16 (Celeste et al., 1990).

In Xenopus and zebrafish, BMP2, 4 and 7 have been implicated, after the onset of zygotic expression, in inducing and maintaining ventro-lateral cell fate during early development. We provide evidence here that a maternally expressed bone morphogenetic protein (BMP), Radar, may control early ventral specification in zebrafish. We show that Radar ventralizes zebrafish embryos and induces the earl...