OBJECTIVE To investigate the effects of two doses of vitamin D given over 1 year on bone density in ambulatory patients on long-term antiepileptic drug (AED) therapy. METHODS We conducted two parallel, randomized, controlled trials in 72 adults (18 to 54 years old) and 78 children and adolescents (10 to 18 years) on long-term AED therapy. They received either low-dose vitamin D 400 IU/day or ...

BACKGROUND Children with chronic intestinal failure (IF) treated with long-term parenteral nutrition (PN) may present with low bone mineral density (BMD). The cause may reflect small body size or suboptimal bone mineralization. OBJECTIVE We assessed growth and bone health in children with severe IF. DESIGN Height, weight, and fracture history were recorded. The lumbar spine bone mass was me...

CONTEXT Whether a child with low bone mineral density (BMD) at one point in time will continue to have low BMD, despite continued growth and maturation, is important clinically. The stability of a characteristic during growth is referred to as "tracking." OBJECTIVE We examined the degree of tracking in bone mineral content (BMC) and BMD during childhood and adolescence and investigated whethe...

the aim of this study was to investigate the effect of high intensity interval training (hiit) on bone mass density in adult male wistar rats. for this purpose, 16 rats (weight 250±20 g and 6 weeks old) were divided into experimental group (n=8) and control group (n=8). after a week of orientation to the training protocol, 8 weeks of incremental hiit was performed. 24 hours after the last train...

Osteopontin (OPN) is an acidic, noncollagenous matrix protein produced by the bone and kidneys. It is reportedly involved in bone resorption and formation. We examined the association between serum OPN levels and bone mineral density in postmenopausal women. Premenopausal women (n=32) and postmenopausal women (n=409) participated in the study. We measured serum osteopontin levels and their rela...

Previous studies have identified 63 single-nucleotide polymorphisms (SNPs) associated with bone mineral density (BMD) in adults. These SNPs are thought to reflect variants that influence bone maintenance and/or loss in adults. It is unclear whether they affect the rate of bone acquisition during adolescence. Bone measurements and genetic data were available on 6397 individuals from the Avon Lon...

Animal models have been widely used to correlate in vivo changes in bone mineral density (BMD) with changes in disease state of bone. In small animal models, e.g. the hindlimb suspension model of bone loss, a non-invasive assessment of BMD is required. X-ray radiography has been surpassed in some cases by quantitative computed tomography (QCT) and dual X-ray absorptiometry (DEXA) quantitation. ...

Phosphorus and calcium are essential for bone health. There is a concern that a low calcium/phosphorus intake ratio resulting from low calcium intake coupled with high phosphorus intake may have a negative effect on bone mineral status, especially in Western countries. The objective of this study was to examine cross-sectionally the influence of habitual phosphorus and calcium intake and the ca...

The perturbation status of vitamin D can be manifested as insufficiency, deficiency and excessiveness. Vitamin D status within the organism is determined by measuring the level of 25(OH)D in the serum. The aim of this paper was to determine the vitamin D status in postmenopausal women with newly diagnosed osteoporosis as well as to correlate vitamin D status with bone mineral density (BMD) and ...

The method for estimating reduced bone mineral density from dental radiographs is discussed in this paper. Dual X-ray absorptiometry is the common technique to determine bone mineral density. Because of high costs and limited availability, it is worthwhile to look for alternative diagnostic techniques. The objective of this study was to investigate the use of Dental Radiographic measurements as...