INTRODUCTION The aim of this study was to develop a clinical-grade, automated, multiplex system for the differential diagnosis and molecular stratification of rheumatoid arthritis (RA). METHODS We profiled autoantibodies, cytokines, and bone-turnover products in sera from 120 patients with a diagnosis of RA of < 6 months' duration, as well as in sera from 27 patients with ankylosing spondylit...

This study aimed to assess the effect of apical periodontitis and its treatment on profile salivary inflammatory markers investigate correlation with serum markers. Saliva samples were collected from 115 recruited participants. Patients reviewed after 1 2 years following treatment. analysed using Multiplex microbead immunoassay for identifying biomarkers’ profile. Biomarker levels compared agai...

AIMS In this pilot, placebo-controlled study, we evaluated whether brief administration of teriparatide (TPTD) in premenopausal women with lower-extremity stress fractures would increase markers of bone formation in advance of bone resorption, improve bone structure, and hasten fracture healing according to magnetic resonance imaging (MRI). METHODS Premenopausal women with acute lower-extremi...

Background Switching patients who remain at high risk of skeletal related events (SREs) despite pamidronate to the more potent bisphosphonate zoledronate, may be an effective treatment strategy. As part of a previously reported clinic study in this setting, we evaluated whether biomarkers for bone resorption, such as Bone-Specific Alkaline Phosphatase (BSAP), bone sialoprotein (BSP), and N-term...

Abstract Purpose To examine the association of maternal bone markers [sclerostin, soluble receptor activator nuclear factor-?B ligand (sRANKL), osteocalcin, 25-hydroxyvitamin D3] with fetal intra-abdominal and subcutaneous adipose tissue deposition birthweight during normal pregnancy. Methods One hundred pregnant women (aged 30.4 ± 5.6 years, mean SD) prepregnancy body mass index = 24.1 4.6 kg/...

Relevance . Drug-associated osteonecrosis is known to cause some pathological changes. The titers of biomarkers responsible for bone metabolism are also subject such They essential in the diagnosis and treatment planning, especially during surgical interventions, because risk osteonecrosis. Purpose – based on data modern scientific literature articles, identifying markers remodeling endothelial...

background: currently, non-invasive methods for screening atrophic gastritis and gastric cancer are lacking. the purpose of this study was to evaluate the value of serological parameters including serum pepsinogen i (pgi), pepsinogen ii (pgii) and pepsinogen i: ii ratio for the screening atrophic gastritis and gastric cancer.   methods : the study population consisted of 132 dyspeptic patients ...

OBJECTIVE Pathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults. METHODS Electronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with objective or subjective measures of SB, sample size ≥50, mean age ≥60years and accelerometer wea...