Synthesis of long peptides is generally considered as a challenge to peptide chemists, in addition producing significant amounts toxic waste, such DMF. Here we show that using solvent-less methods, ball milling, enabled the production hexapeptide Boc-(Ala-Phe-Gly)2-OBn at gram scale with high overall yield (77 %, 5 linear steps). This longest chain synthesized mill date, which amino acid sequen...

Clarithromycin (CLA), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. The aim of this investigation was to prepare CLA nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (SLS) and polyvinyl pyrrolidone (PVP) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. Different weight rati...