The large post-reproductive life span reported for the free-living hermaphroditic nematode, Caenorhabditis elegans, which lives for about 10 days after its 5-day period of self-reproduction, seems at odds with evolutionary theory. Species with long post-reproductive life spans such as mammals are sometimes explained by a need for parental care or transfer of information. This does not seem a su...

Mitogen-activated protein kinase (MAPK) signaling cascades are activated by diverse stimuli such as growth factors, cytokines, neurotransmitters and various types of cellular stress. Our evolving understanding of these signal cascades has been facilitated by genetic analyses and physiological characterization in model organisms such as the nematode Caenorhabditis elegans. Genetic and biochemica...

Caenorhabditis elegans nematodes are broadly used to investigate the impact of environmental factors on animal physiology and behavior. Here, C. with internalized paramagnetic nanoparticles were placed inside a magnetic field (MF) explore its effects locomotion. We hypothesized that combined external MF affect elegans’ locomotion machinery. To test our hypothesis, we adult fed bacteria mixed 1 ...

BACKGROUND: Streblus asper Lour., has been reported to have anti-aging and neuroprotective efficacies in vitro. OBJECTIVE: To analyze the anti-aging, anti-photoaging of S. Caenorhabditis elegans. METHODS: C. elegans (wild type gene specific mutants) were treated with extract analyzed for lifespan other health benefits through physiological assays, fluorescence microscopy, qPCR Western blot. RES...

Neonicotinoids are potent agonists of nicotinic acetylcholine receptors that exert insecticidal effects by causing abnormal excitation the nervous system. and their metabolites effect in mammals, including humans, have become a concern. In present study, we evaluated chronic exposure two neonicotinoids, acetamiprid (ACE) clothianidin (CTD), on Caenorhabditis elegans. We used 1, 10, 100, 1000 µM...

organism The nematode Caenorhabditis elegans is a genetically tractable multicellular organism that has been the subject of intense study for more than four decades. It has been successfully used as a model system to address fundamental questions in multiple fields of biology, including development, neurobiology and aging. In recent years, this tiny nematode worm has been applied to the study o...

Patterning of C. elegans vulval cell fates relies on inductive signaling. In this induction event, a single cell, the gonadal anchor cell, secretes LIN-3/EGF and induces three out of six competent precursor cells to acquire a vulval fate. We previously showed that this developmental system is robust to a four-fold variation in lin-3/EGF genetic dose. Here using single-molecule FISH, we find tha...

Transposons are discrete segments of DNA capable of moving through the genome of their host via an RNA intermediate in the case of class I retrotransposon or via a "cut-and-paste" mechanism for class II DNA transposons. Since transposons take advantage of their host's cellular machinery to proliferate in the genome and enter new hosts, transposable elements can be viewed as parasitic or "selfis...