Four small molecular receptors of vancomycin have been designed to make part of a novel biosensor device based on the FTIR-ATR detection: N-Boc (2a) or N-Ac (2b)-6-aminocaproyl-D-Ala-D-Ala and N-Boc (3a) or N-Ac (3b)-6-aminocaproyl-D-Ala-d-Ser. Using an original microbiological approach to assess the competition of compounds with the natural target of vancomycin in bacteria, EC(50) values of 6....

The BoC was pioneered in the UK by Dr. David Challis and his colleagues at the Personal Social Services Research Unit (PSSRU), University of Manchester. While conventional projections of care needs often assume that a growing population of older persons will demand a proportionately greater number of residential LTC beds, the BoC emphasizes that the need for such beds will be determined as well...

The Front Cover shows that a medium-chain alcohol dehydrogenase modified in the loop is efficiently catalyzing N-Boc-3-pyrrolidone to produce (S)-N-Boc-3-pyrrolidinol. In their Research Article, H. Wang and co-workers proposed loop-loop interaction region acts like “bridges” between loops could be used adjust conformational dynamics of enzyme, thus modifying its catalytic efficiency. Combined w...

This paper features an experimental Galileo PRS receiver with a novel BOC tracking method and interference mitigation algorithms in time, frequency and spatial domain. The modified BaSE-II hardware architecture is outlined including a newly designed miniaturized 2x2 array antenna. A new, reliable and robust BOC tracking method is presented that fully exploits the subcarrier accuracy and allows ...

1 Chemistry 2 Liquid-phase synthesis 3 Solid-phase synthesis 3.1 Boc SPPS 3.2 Fmoc SPPS 3.3 BOP SPPS 4 Solid supports 4.1 Polystyrene resin 4.2 Polyamide resin 5 Protecting groups 5.1 Fmoc protective group 5.2 Boc protective group 5.3 Benzyloxy-carbonyl (Z) group 5.4 Alloc protecting group 5.5 Lithographic protecting groups 6 Activating groups 6.1 Carbodiimides 6.2 Aromatic oximes 7 Synthesizin...

The chiral center at the substituted atom of the tetra-hydro-furanyl ring in the title compound, C(13)H(17)N(5)OS, has an R configuration. The methyl-sulfanylpyrimidine group and the pyrazole ring are almost coplanar [the maximum deviation from this plane is 0.070 (4) Å], the N-Me substituent being displaced from the methyl-sulfanylpyrimidine-pyrazole plane by 0.880 (4) Å. The secondary amine g...

Not least due to the widespread use of meta modelling concepts, model transformation techniques have reached a certain level of maturity [5]. Nevertheless, there is a lack of common community knowledge concerning different transformation approaches fitting different requirements and application areas. The aim of this paper is to present the BOC model transformer, an industry-proven transformati...

Acetone fractionated peroxidase from crude extract of Brassica oleracea leaves (Cabbage) was purified in three steps on chromatographic columns, using Sp-Sepharose, DEAE-Sepharose and Con A-Sepharose. The specific activity of purified main isoenzyme (BOC-POD) is 1887 u/mg protein with RZ: 3.1, which is 172 times more than the RZ of crude extract with 4.3% recovery. The molecular weight of BOC-P...

Let G be a crystallographic group in I R n. A Dirichlet stereohedron for G is any region in the Voronoi diagram of any orbit of G. We prove that Dirichlet stereohedra for three-dimensional crystallographic groups containing reeexions in three, two or one independent directions cannot have more than eight, eighteen and fteen facets respectively. We show examples where the three bounds are attain...