Background. Burning mouth syndrome (BMS) is defined as a chronic burning sensation in the oral mucosa that can not be attributed to its pathological findings. Current opinion is that the clinical symptoms of BMS can be attributed to neurological disorders caused by disturbances in the processes of sensory information on various levels of the nervous system. In its etiology, dysfunction of the n...

BACKGROUND The long-term safety and efficacy of drug-eluting stents (DES) have been questioned recently. METHODS AND RESULTS Between July 2002 and June 2005, 10,629 patients undergoing elective percutaneous coronary intervention with either DES (n=3064) or bare-metal stents (BMS, n=7565) were enrolled in a prospective registry comprising 13 hospitals. We assessed the cumulative incidence of m...

Despite an excellent initial response to first-line hormonal treatment, most patients with metastatic prostate cancer will succumb to a hormone-refractory form of the disease. Because these tumors are still dependent on a functional androgen receptor (AR), there is a need to find novel and more potent antiandrogens. While searching for small molecules that bind to the AR and inhibit its transcr...

BACKGROUND Research trials have shown improved short-term outcome with drug-eluting stents (DES) over bare metal stents (BMS) in saphenous vein graft (SVG) percutaneous coronary intervention (PCI), primarily by reducing target vessel revascularization (TVR) for in-stent restenosis. We compared the outcomes in patients undergoing SVG stent implantation treated with DES or BMS. In exploratory ana...

BACKGROUND The main causes of late (>1 month) stent thrombosis (ST) are stent uncoverage, malapposition, and neoatherosclerosis. First-generation drug-eluting stents were associated with higher rate of late ST compared with bare-metal stents (BMS), especially in patients with ST-segment-elevation myocardial infarction. Second-generation everolimus-eluting stents (EES) have shown similar rate of...

Katakam PV, Gordon AO, Sure VN, Rutkai I, Busija DW. Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats. Am J Physiol Heart Circ Physiol 307: H493–H503, 2014. First published June 14, 2014; doi:10.1152/ajpheart.00091.2014.—Mitochondrial depolarization following ATP-sensitive potassium (mitoKATP) channel ac...

BACKGROUND Mitochondrial dysfunction is one of the main causes of non-alcohol fatty liver disease (NAFLD). [18F]-BMS-747158-02 (18F-BMS) which was originally developed as a myocardial perfusion imaging agent was reported to bind mitochondrial complex-1 (MC-1). The aim of this study was to investigate the potential use of 18F-BMS for evaluating hepatic MC-1 activity in mice fed a methionine- and...

Chronic myeloid leukemia (CML), a hematopoietic stem cell (HSC) disorder, cannot be eradicated by conventional chemotherapy or the tyrosine kinase inhibitor (TKI) imatinib mesylate (IM). This disease persistence results from a population of quiescent CML HSC that are also not effectively targeted by the second generation BCR-ABL TKIs, dasatinib (DAS) or nilotinib in vitro. To target CML stem/pr...

The RON receptor tyrosine kinase is a therapeutic target for cancer treatment. Here, we report therapeutic effect andphenotypic change of breast cancer cells in response to BMS-777607, a RON tyrosine kinase inhibitor. Treatment of breast cancer cells with BMS-777607 at therapeutic doses inhibited cancerous clonogenic growth but had only minimal effect on cell apoptosis. Significantly, BMS-77760...

Despite the efficacy of antidepressants such as amitriptyline for alleviating burning mouth syndrome (BMS) [1,2], BMS may persist after antidepressant monotherapy. However, recent case reports have shown that aripiprazole (APZ) augmentation can reduce chronic pain resistant to other treatments [3]. Herein, we present two cases in which patients with BMS responded well to a very low dose of APZ ...