The ETV6 gene (previously known as TEL) belongs to the ETS (E26 transformation specific) family of transcription factors characterized by 2 important domains: the Cterminal Ets domain responsible for specific DNA-binding activities and the N-terminal helix–loop–helix (HLH) oligomerization domain, also known as pointed (PNT) or sterile alpha motif (SAM), that mediates protein–protein interaction...

•Enasidenib is an inhibitor of mutant IDH2 that releases the block in cellular differentiation imposed by aberrant production 2-hydroxyglutarate.•Mechanisms action azacitidine and enasidenib involve regulation epigenome.•The enhanced anti-leukemic activity combining leads to greater reductions DNA methylation. Azacitidine are two therapies available for treatment acute myelogenous leukemia (AML...