OBJECTIVE To study cycle control, compliance and safety of a transdermal contraceptive patch in Thai women. MATERIAL AND METHOD Sixty-nine healthy women were assigned to receive 3 cycles of contraceptive patch (ethinyl estradiol 20 microg and norelgestromin 150 miccrog/day). All participants aged 18-45 years were invited to participate at the family planning clinic at King Chulalongkorn Memor...

Abstract Spontaneous intracranial hypotension (SICH) is the emerging cause of orthostatic headache as it has been better recognized in recent years. SICH happens due to spinal cerebrospinal fluid (CSF) leak; however, manifestations are predominantly cranial and hence imaging includes brain spine. There few characteristic features be concerned about diagnose patients with vague symptoms or low c...

BACKGROUND The cerebrospinal fluid (CSF) leakage could be happened spontaneously or related to the procedures such as spinal anesthesia, epidural anesthesia, CSF tapping, intrathecal chemotherapy or other spinal procedures. The leakage of CSF leads to intracranial hypotension of which distinguishing clinical feature is orthostatic headache. The epidural blood patch is a gold-standard treatment ...

BACKGROUND Donepezil is an acetylcholinesterase inhibitor indicated for Alzheimer's disease. The aim of this randomized, single-blind, placebo-controlled, single-dose, dose-escalation study was to investigate the safety, tolerability, and pharmacokinetics of the donepezil patch in healthy male subjects. METHODS Each healthy male subject received a single transdermal donepezil patch (72 hours ...

Experimental investigation of the ultimate resistance of slender, steel-plate girder web panels to combined shear-and-patch loading indicates significant interaction between shear loading and patch loading. However, an existing interaction formula is based on experimental results. Herein, an improved design procedure for slender plate girders subjected to combined shear and patch loading is pro...