BACKGROUND Lung cancer is among the most frequently diagnosed types of cancer worldwide, with high morbidity and mortality. Metastasis accounts for the deadliest and most poorly understood feature of lung cancer. Herein, we demonstrate that SND1 (also known as p100) acts as a candidate metastasis activator and is targeted by microRNA-320a (miR-320a) in lung cancer cells. METHODS p100 expressi...

The purpose of this investigation was to study the effect of time of day on the relationship between lactate (LT) and ventilatory thresholds (VT) of pulmonary oxygen uptake (VO2). Seven moderately active male volunteers (26.3 ± 3.0 years, 1.74 ± 0.08 m, 76 ± 5 kg) performed a maximal incremental test (increases of 30 W every 2 min) on a cycle ergometer on consecutive days at 0900 h, 1400h and 1...

Background: Lactic acidosis (LA) and severe hyperlactataemia (HL) are infrequent but serious complications of antiretroviral therapy which have been associated with a high fatality rate. Methods: In a multinational retrospective cohort study LA was defined as arterial blood pH <7.35, bicarbonate <20 mmol/l and lactate above normal and HL as confirmed blood lactate >5 mmol/l. Logistic regression...

OBJECTIVE Stair climbing-descending exercise (ST-EX) is a convenient method to increase exercise intensity. We compared the acute effect of ST-EX on lowering postprandial hyperglycemia with that of constant bicycle exercise (BI-EX) performed at the same heart rate (HR). RESEARCH DESIGN AND METHODS Seven people with type 2 diabetes and seven with impaired glucose tolerance volunteered for this...

Background: Lactic acidosis in cardiac surgical patients is a manifestation of systemic inflammation and excess pro-inflammatory cytokine production. This investigation was designed to integrate basic concepts about lactate acidosis with a clinically used of serum lactate in patients under coronary artery bypass surgery (CABG) by on pump method. Methods: From August to September 2012, 15 patie...

Objective: Acute mesenteric ischemia (IMA) is a vascular emergency with broad variability of clinical presentations and non-specific laboratory findings. Therefore, there is a significant need for reliable serological markers of ischemia. Various laboratory studies may be performed for suspected AMI, but in general, such studies will not establish the diagnosis.Me...

The modulation of auditory event-related potentials (ERP) by attention generally results in larger amplitudes when stimuli are attended. We measured the P1-N1-P2 acoustic change complex elicited with synthetic overt (second formant, F2Δ=1000Hz) and subtle (F2Δ=100Hz) diphthongs, while subjects (i) attended to the auditory stimuli, (ii) ignored the auditory stimuli and watched a film, and (iii) ...

BACKGROUND Lactic acidosis (LA) and severe hyperlactataemia (HL) are infrequent but serious complications of antiretroviral therapy that have been associated with a high fatality rate. METHODS In a multinational retrospective cohort study, LA was defined as arterial blood pH<7.35, bicarbonate <20 mmol/l and lactate above normal, and HL as confirmed blood lactate >5 mmol/l. Logistic regression...

Background: Late preterm neonates may have the external appearance and behavior similar to their counterparts.However, they are susceptible to various neonatal morbidities , due to their physiological and metabolical immaturity.To assess the correlation between cord blood arterial lactate levels and base excess with the development ofrespiratory distress in late preterm neonat...