To investigate why mortality from stroke in people of Afro-Caribbean origin is twice the average for England and Wales, we examined 1166 European and Afro-Caribbean people in London. Age-standardized median systolic blood pressure was 6 mm Hg higher (128 versus 122 mm Hg) in Afro-Caribbean than European men and 17 mm Hg higher (135 versus 118 mm Hg) in Afro-Caribbean than European women. Migran...

The effects of reproduction and maternal investment (i.e., milk transfer) on trace element levels remain poorly understood in marine mammals. We examined the blood dynamics of mercury (Hg) and selenium (Se) during lactation in the northern elephant seal (Mirounga angustirostris), a top predator from the North Pacific Ocean. Total Hg and Se levels were measured in whole blood and milk of 10 moth...

OBJECTIVE To determine the value of monitoring blood pressure by quantifying the probability that observed changes in blood pressure reflect true changes. DESIGN Analysis of blood pressure measurements of patients in the perindopril protection against recurrent stroke study (PROGRESS). SETTING Randomised placebo controlled trial carried out in 172 centres in Asia, Australasia, and Europe. ...

COBURN, R. F., AND L. B. MAYERS. Myoglobin 02 tension determined from measurements of carboxymyoglobin in skeletal muscle. Am. J. Physiol. 220(l) : 66-74. 1971.-We have developed a method of estimating muscle intracellular oxygen tension in vivo, using myoglobin as an oxygen tension indicator. The method is based on the competition of oxygen and carbon monoxide for binding sites on myoglobin an...

BACKGROUND Prior unblinded studies have suggested that catheter-based renal-artery denervation reduces blood pressure in patients with resistant hypertension. METHODS We designed a prospective, single-blind, randomized, sham-controlled trial. Patients with severe resistant hypertension were randomly assigned in a 2:1 ratio to undergo renal denervation or a sham procedure. Before randomization...

BACKGROUND Mercury (Hg) is a ubiquitous pollutant that negatively affects fetal and child neurodevelopment at accidental high-dose exposure. Some studies indicate that Mediterranean populations could be at risk of prenatal exposure to mercury through fish consumption. OBJECTIVES To assess the prenatal exposure to total mercury (T-Hg), both inorganic and organic, in newborns by analyzing the T...

Mercury (Hg) may significantly impact the pathogenesis of autism spectrum disorders (ASDs). Lab results generated by Vitamin Diagnostics (CLIA-approved) from 2003-2007, were examined among subjects diagnosed with an ASD (n=83) in comparison to neurotypical controls (n=89). Blood Hg levels were determined by analyzing Hg content in red blood cells (RBC) using cold vapor analysis, and consistent ...

Raised blood pressure is a leading cause of morbidity and mortality worldwide; improved nutritional approaches to population-wide prevention are required. Few data are available on dietary phosphorus and blood pressure and none are available on possible combined effects of phosphorus, magnesium, and calcium on blood pressure. The International Study of Macro- and Micro-Nutrients and Blood Press...

COBURN, R. F., AND L. B. MAYERS. Myoglobin 02 tension determined from measurements of carboxymyoglobin in skeletal muscle. Am. J. Physiol. 220(l) : 66-74. 1971.-We have developed a method of estimating muscle intracellular oxygen tension in vivo, using myoglobin as an oxygen tension indicator. The method is based on the competition of oxygen and carbon monoxide for binding sites on myoglobin an...