At last, a mouse model of the natural history of chronic myeloid leukemia (CML) has been elegantly engineered. CML is hardly a public health menace, occurring in only 1–2 per 100,000 people. Nonetheless, the disease is the " poster child " of genetically based diagnosis and treatment, as all cases of CML have the BCR-ABL trans-location, which is both a diagnostic marker of the disease and a tar...

background: induction chemotherapy for acute lymphoblastic leukemia achieves complete remis sion in over 90% of children. it is apparent therefore that many patients in clinical remission and with out residual disease detectable by conventional light microscopy of peripheral blood or bone marrow films still harbor viable cells of the original disease mrd analysis does have a useful role to play...

Marked patient-to-patient variation is observed when blood or marrow from AML patients is examined using colony methods in culture. Concentrations of the progenitors of colonies change with time during the course of the disease. We asked whether blast progenitor properties were more stable. We measured blast cell self-renewal and drug sensitivity (adriamycin and cytosine arabinoside) repeatedly...

In six patients with acute leukemia (about 2% of the patients referred for acute lymphoblastic leukemia) the blast cells invading bone marrow and blood showed all the cytologic, cytochemical, and electron microscopy features of Burkitt's tumor cells. The presence of monoclonal surface immunoglobulins (their synthesis being proved by in vitro culture experiments), the binding of IgG aggregates, ...

Given the sophisticated nature of the blast phenomenon in relation to structures, it is of significance to accurately investigate the structure behavior under blast loads. Due to its rapid and transient nature, blast loading is one of the most important dynamic loadings on the structures. Since masonry materials are widely used as the partition and bearing walls in the existing and newly-built ...

Recently, Unmanned Aerial Vehicle (UAV) has been usefully used to produce precise crop information on farmland. The purpose of this study is develop a technology for estimating rice yield distribution in paddy field damaged by blast using UAV imagery. We analyzed the change sensing according disease occurrence images 2021. correlation between NDVI vegetation index and showed high value 0.8 or h...

Blast cells from 6 of 50 patients with acute lymphoblastic leukemia (ALL) displayed intracytoplasmic mu chains in the absence of detectable light chains and surface immunoglobulins. These cells also expressed lalike and common ALL antigens. Terminal deoxynucleotidyltransferase was detectable in 2 of 5 cases tested. These blast cells are probably related to early B-cell precursors (pre-B cells)...

Serial determinations of adenosine deaminase (ADA) activity in 69 patients with chronic myelogenous leukemia provided a biochemical marker of disease activity. Eighty-nine % of patients in the accelerated phase had an elevation of ADA activity. This elevation was not a direct reflection of an increased absolute blast count. Furthermore, five of seven patients studied serially from the stable ph...

Blast crisis, closely resembling acute leukemia, is the usual terminal event in chronic myeloid leukemia. Using physical ("fingerprint") and cultural (colony-forming) methods, we have demonstrated distinctive patterns in the stable phase of chronic myeloid leukemia and in blast crisis. An unusual fingerprint alteration preceding the onset of the terminal phase is noted, and cell culture perturb...

A number of experimental models of blast brain injury have been implemented in rodents and larger animals. However, the variety of blast sources and the complexity of blast wave biophysics have made data on injury mechanisms and biomarkers difficult to analyze and compare. Recently, we showed the importance of rat position toward blast generated by an external shock tube. In this study, we furt...