Background: The role of infectious agents in prostate cancer development has been considered for many years. Polyomaviruses are suspected to be related to human malignancies and they have been frequently detected from various human cancers. Aim: This study was performed to investigate presence of large t antigen encoded by Merkel Cell polyomavirus (MCV), JC polyomavirus (JCV), BK polyomavirus (...

PCR-based molecular assays have a central role in polyomavirus diagnostics. To assure optimal performance, target sequences should be regularly updated according to newly available sequences. The aim of this study was to review our in-house polyomavirus BK (BKV) and JC (JCV) real-time PCR assays. Database analysis revealed variations in the BKV target region which might affect the assay perform...

We report a case of a 64-year-old woman who underwent left adrenalectomy with removal of a 8,5 cm clinically non-functioning adrenocortical adenoma and a 4-cm myelolipoma. Molecular testing for viral infection demonstrated the presence of cytomegalovirus (CMV) DNA sequences in the adrenal adenoma, but not in the myelolipoma (confirmed by immunohistochemistry). Moreover, the adrenal adenoma was ...

Several sexually transmitted viruses have been associated with the development of Kaposi's sarcoma (KS), a highly vascularized multi-focal neoplasm, characterized by the presence of spindle-shaped and endothelial cells, fibroblasts and macrophages. As BK virus (BKV) sequences were found in 100% of primary KS and 75% of KS cell lines, we established an experimental model to test whether BKV may ...

BACKGROUND Polyomavirus-associated nephropathy (PVAN) is a serious complication and cause of graft loss in kidney transplant recipients. In the absence of specific antiviral drugs, early detection of the disease and reduction of immunosuppressive regimen is the cornerstone of therapy. Cidofovir, a nucleoside analogue, has been found to inhibit BK virus (BKV) replication in vitro and has been pr...

Polyomavirus BK reactivation is common in renal transplant recipients and may cause nephropathy with significant graft dysfunction. The induction of anti-double stranded DNA (anti-dsDNA) antibodies by BKV has been described in experimental animals and during primary infection, and has been implicated in the pathogenesis of systemic lupus erythematosus. This study evaluated the occurrence of ant...

BK polyomavirus (BKV) nephropathy is a major concern in renal transplantation. Its main consequence is graft loss, which occurs in more than 50% of the cases. De novo renal cell carcinoma in renal allograft is a very rare event. Most of these tumors are papillary or clear cell carcinomas. We report herein the first case of collecting duct carcinoma of the renal allograft in a kidney-pancreas al...

Amaç: Böbrek nakli, böbrek yetmezliğinin en önemli ve başarılı tedavi yöntemidir. Bu çalışmada, nakli alıcılarında nakil öncesi sonrası ilk altı ayda Cytomegalovirus (CMV), BK virüs (BKV) bakteriyel etkenlerin sıklığının araştırılması amaçlanmıştır. 
 Gereç Yöntem: Fakültemiz Organ Nakli Merkezinde yapılan hastalardan, nakilden bir hafta önce sonra birinci, üçüncü altıncı aylarda alınan ka...