Enzyme induction in Escherichia coli is stimulated by certain 5-amino-2,4-bis(substitutedamino)pyrimidines (Kunkee, 1960a). Other 2,4diaminopyrimidines have been reported to be antagonists of folic acid (Hitchings et al., 1952; Doctor, 1956). Since there are indications that the stimulation of enzyme induction involves nucleic acid metabolism (Kunkee, 1960b) and since folic acid is involved in ...

2-Methoxy-4,4’-bis(methylthio)benzhydrylamine (10) and the corresponding disulfoxide were prepared and tested as a model amide protecting groups for their stability toward acidic conditions. Subsequently, the novel 4-[4,4’-bis(methylsulfinyl)-2-o~-(9-fluorenylmethylo~c~bonyl) benzhydrylaminolbutanoic acid (SCAL) handle (9) has been prepared and applied to solid-phase peptide synthesis of C-term...

Bifunctional dendrons based on 2,2-bis(methylol)propionic acid (bis-MPA) are highly desirable scaffolds for biomedical applications. This is due to their flawless nature and large and exact number of functional groups as well as being biodegradable and biocompatible. Herein, we describe a facile divergent growth approach to their synthesis from monobenzylated tetraethylene glycol and post funct...

Previous information on the catabolism of valine has been obtained by taking advantage, for the most part, of the gluconeogenic property of valine and using glucose as an indicator of its intermediary metabolism. Thus, Rose et al. (1) reported that valine and a-ketoisovaleric acid have similar gluconeogenic effects, both contributing 3 of their carbon atoms to glucose formation in phlorizinized...

In milk and milk products, a number of organic acids naturally occur. We investigated the contents of some naturally occurred food preservatives (sorbic acid, benzoic acid, propionic acid, nitrite, and nitrate) contained in domestic and imported cheeses to establish the standard for the allowable range of food preservatives content in cheese. 8 kinds of domestic precheeses (n=104), 16 kinds of ...

effect of different planting ratios of oat (avena sativa l.) and vetch (vicia sativa l.) was assessed on quality and quantity of forage and silage in an intercropping system as completely randomized block design (rcbd) with four replications. the treatments were different planting ratios of oat and vetch including 0:100, 20:80, 40:60, 50:50, 60:40, 80:20 and 100:0 (oat-vetch) formed as replacem...

1. Sheep fed at a constant rate were infused intraruminally with [1-(14)C]-acetate, -propionate or -butyrate during 5hr. periods. 2. Volatile fatty acids were estimated in the rumen contents and steady-state conditions were obtained. 3. Of the butyric acid carbon 60% was in equilibrium with 20% of the acetic acid carbon, and 2-3g.atoms of carbon were interconverted/day. 4. Little interconversio...

Three new prodrugs, [prodrug 1: 4-[bis(2-iodoethyl)amino]-phenyloxycarbonyl-L-glutamic acid; prodrug 2: 3-fluoro-4-[bis(2-chlorethyl)amino]benzoyl-L-glutamic acid; and prodrug 3: 3,5-difluoro-4-[bis(2-iodoethyl)amino]benzoyl-L-glutamic acid] have been assessed for use with a mutant of carboxypeptidase G2 (CPG2, glutamate carboxypeptidase, EC 3.4.17.11,) engineered to be tethered to the outer tu...