Information about mood reactions to naturally occurring stress in remitted bipolar patients may help elucidate the mechanism by which stressors influence the propensity to manic or depressive relapse in these patients. Using the experience sampling method (ESM), we therefore investigated negative and positive mood states and their reactivity to daily hassles and uplifts in 38 outpatients with r...

psychotic disorders and bipolar disorder (8) and between bipolar disorder and major depressive disorder (9). Although family and twin studies can estimate the shared heritability across disorders, they cannot identify the genetic loci contributing to this overlap. To date, evidence implicating specifi c chromosomal regions and genes in the shared liability to psychotic and mood disorders has la...

OBJECTIVES The goal of this retrospective study was to examine factors differentiating persons with bipolar disorder who did or did not have comorbid lifetime substance use disorders (SUD) at an index assessment. We also explored the chronology of onset of mood and SUD. METHODS We studied 146 subjects with DSM-defined bipolar disorder. Subgroups with and without lifetime SUD were compared on ...

July 01, 2006 | Bipolar Disorder [1], Personality Disorders [2], Schizoaffective [3], Schizophrenia [4], Borderline Personality [5], Antisocial Personality Disorder [6], Mood Disorders [7], Bipolar II Disorder [8], Mania [9], Forensic Psychiatry [10], Neuropsychiatry [11], Addiction [12], Alcohol Abuse [13], Dysthymia [14] By Silvio Bellino, MD [15], Erika Paradiso, MD [16], and Filippo Bogetto...

Numerous studies have been done on using low serum lithium levels for maintenance therapy of bipolar mood disorder over the past 30-40 years. In this study we sought for the most suitable serum lithium level that having longer relapse's interval periods and less side effects as to recommended it as a maintenance serum lithium level. Thus, we studied 90 patients with bipolar mood disorder (accor...

Background Previous research has examined the association of affective temperaments, as measured by the TEMPS-A, with DSM bipolar disorders. However, the relation of the TEMPS-A with risk for bipolar disorder remains unclear. The present study examined the association of affective temperaments with psychopathology, personality, and functioning in a nonclinically ascertained sample of young adul...

Bipolar disorder is a chronic disorder of mood which leads to episodes of either elevated mood or depression in a sizable number of adults in the community (1%). Though the prevalence rates in the elderly are lower in the community (up to 0.1%), there is significantly higher morbidity in protected environments like care homes and hospital settings where prevalence rates may be as high as 10%. B...

Investigated the association between family functioning and conflict and their links with mood disorder in parents and with children's risk for bipolar disorder. Participants were 272 families with a child between the ages of 5-17 years. Parents' history of psychiatric diagnoses and children's current diagnoses were obtained via semi-structured interviews. Parent report on the Family Assessment...

Research has demonstrated impairments in executive functions in Bipolar Mood Disorder patients. Evidence shows that this impairment is present in both periods of active symptoms of the disorder, as well as euthymic stages, and is compounded by mood episodes, especially manic phases. The purpose of this study was to compare the executive performance of a sample of Brazilian bipolar patients in d...

The neurobiology of bipolar disorder, a chronic and systemic ailment is not completely understood. The bipolar phenotype manifests in myriad ways, and psychopharmacological agents like lithium have long term beneficial effects. The enzyme glycogen synthase kinase 3 (GSK3) has come into focus, as lithium and several other mood stabilizing medications inhibit its activity. This kinase and its key...