Hyperspectral imaging has proven significance in bio-imaging applications and it has the ability to capture up to several hundred images of different wavelengths offering relevant spectral signatures. To use hyperspectral imaging for in vivo monitoring and diagnosis of the internal body cavities, a snapshot hyperspectral video-endoscope is required. However, such reported systems provide only a...

In diverse biomedical imaging applications, one often encounters the need for high resolution images of an area larger than the eld of view of the imaging device. Traditionally the human expert reads diagnostic information from several partial images, manually or mentally assembling them into a whole. In recent years, there has been a sharp increase in the use of computer mosaic methods for bio...

Quantitative analysis of bioimaging data is often skewed by both shading in space and background variation in time. We introduce BaSiC, an image correction method based on low-rank and sparse decomposition which solves both issues. In comparison to existing shading correction tools, BaSiC achieves high-accuracy with significantly fewer input images, works for diverse imaging conditions and is r...

The non-specific adhesion of spherical micro- and nano-particles to a cell substrate is investigated in a parallel plate flow chamber. Differently from prior in-vitro analyses, the total volume of the particles injected into the flow chamber is kept fixed whilst the particle diameter is changed in the range 0.5-10 microm. It is shown that: (i) the absolute number of particles adherent to the ce...

A novel and easily accessible luminescent iridium(iii) complex [Ir(tpy)2(N^N)]PF6 (, tpy = 2-(p-tolyl)pyridine, N^N = 4-[(4-amino-3-nitrophenoxy)-methylene]-4'-methyl-2,2'-bipyridine) for the sensing of HOCl has been designed and synthesized. The detection strategy is based on the HOCl-promoted cleavage of the PET quenching 4-amino-3-nitrophenyloxy moiety of the weakly emissive complex , which ...

Predicting the future is a dangerous undertaking at best, and not meant for the faint-hearted. However, viewing the advances in molecular medicine, genomics and proteomics, it is easy to comprehend those who believe that molecular imaging methods will open up new vistas for medical imaging. The knock on effect will impact our capacity to diagnose and treat diseases. Anatomically detectable abno...

In this paper we review the recent progress toward single-particle imaging of biological molecules at x-ray free-electron laser (XFEL) facilities. We describe the progression from biological imaging at synchrotrons to imaging at XFELs, discuss recent successes, and point out specific challenges associated with imaging at XFEL facilities.

Computer simulations have played an important role in the design and evaluation of imaging sensors with applications in remote sensing [1] and consumer photography [2-7]. In this paper, we provide an example of computer simulations used to guide the design of imaging sensors for a biomedical application: We consider how sensor design, illumination, measurement geometry, and skin type influence ...