Molecular markers for renal cell carcinoma could guide early detection of localized disease in defined populations at high risk for the disease or early disease recurrence after nephrectomy for renal cell carcinoma. In addition, sensitive and specific markers may provide surrogate end points for clinical trials of treatment and/or disease prevention. Powerful techniques of genomic and proteomic...

線溶検査は，フィブリン分解というダイナミックに変化する動態を把握するための生体情報ツールである．多くの血栓性疾患において線溶系マーカーであるプラスミンとα2プラスミン インヒビター複合体（plasmin-α2plasmin inhibitor complex: PIC）は，凝固系マーカーのトロンビン-アンチトロンビン複合体（thrombin-antithrombin TAT）と比較的良好な相関を示す．D-dimerは，架橋化フィブリンが形成され主にプラスミンにより分解されたことを示す凝固線溶系マーカーである．フィブリノゲン・フィブリン分解産物（fibrinogen and fibrin degradation products: FDP）は，プラスミンなどがフィブリノゲンや架橋化フィブリンを分解することにより生じる．いずれも特異抗体を用いて免疫学的に定量されるため，異なる測定試薬間で...

Introduction: Various therapeutic options such as Calcitonin are suggested for patients with low bone density. However, the efficacy remains uncertain in all patients. C-telopeptide of type I collagen (CTx) is the authentic bone marker which is recently used to assess the bone turnover. This study aimed at revealing the therapeutic effects of Calcitonin on osteopenic women via ...

BACKGROUND AND AIM: Oral lichen planus (OLP) is a chronic, autoimmune, inflammatory disease. The progression of OLP to oral squamous cell carcinoma (OSCC) has generated a longstanding controversy about the details of this malignant transformation potential. This study aimed to do a systematic review on the molecular markers related to the malignant transformation of OLP.METHODS: We searched the...

Expressed sequence tags simple sequence repeats (EST-SSRs) are important sources for investigation of genetic diversity and molecular marker development. Similar to genomic SSRs, the EST-SSRs are useful markers for many applications in genetics and plant breeding such as genetic diversity analysis, molecular mapping and cross-transferability across related species and genera. In spite of low po...