In this work we redefine the concept of biological importance and how to compute it, based on a model of complex networks and random walk. We call this new procedure, theoretical knock-out (KO). The proposed method generalizes the procedure presented in a recent study about Oral Tolerance. To devise this method, we make two approaches: algebraically and algorithmically. In both cases we compute...

5 Modelling mutational degeneration 23 5.1 Error thresholds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 5.1.1 The prototype model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 5.1.2 Methods of analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 5.1.3 Characterization of error thresholds . . . . . . . . . . . . . . . . . . . . ....

The critical aspects of biosafety, biosecurity, and biocontainment have been in the spotlight in recent years. There have also been increased international efforts to improve awareness of modern practices and concerns with regard to the safe pursuit of life sciences research, and to optimize current oversight frameworks, thereby resulting in decreased risk of terrorist/malevolent acquisition of...

With our growing awareness of the complexity underlying biological phenomena, our need for computational models becomes increasingly apparent. Due to their properties, biological clocks have always lent themselves to computational modelling. Their capacity to oscillate without dampening--even when deprived of all rhythmic environmental information--required the hypothesis of an endogenous oscil...

We considered a multiblock molecular model of biological evolution, in which fitness is a function of the mean types of alleles located at different parts (blocks) of the genome. We formulated an infinite population model with selection and mutation, and calculated the mean fitness. For the case of recombination, we formulated a model with a multidimensional fitness landscape (the dimension of ...

Biomarkers are potentially powerful tools for use in research and regulation. Their derivation from biologic specimens collected from human subjects does, however, present many ethical implications. Ethical issues are relevant in almost each facet of human biomarker research studies: design, identification and recruitment of subjects, handling and use of the data, and interpretation and communi...

We construct a descriptive toy model that considers quantum effects on biological evolution starting from Chaitin's classical framework. There are smart evolution scenarios in which a quantum world is as favorable as classical worlds for evolution to take place. However, in more natural scenarios, the rate of evolution depends on the degree of entanglement present in quantum organisms with resp...

This short article hypothesizes that the major reason for persistent disease despite biologic therapy is the inappropriately late timing of therapy with biologic agents. There is clear evidence to support this hypothesis. This short review will indicate that patients treated at an earlier phase of disease can achieve a clinical remission rate of 70% and a response rate of above 95%.

to study and determine  effect of salinity on relationship between  agronomic  characteristics and grain yield, 167  of  the  seri/babax recombinant wheat inbred  lines (ril) together with two parents were evaluated using alpha latice design with two replications under two conditions (salt stress and normal), in zabol field station in 2011-12 cropping season. fourteen  traits  including: some a...