BACKGROUND/AIM The tumor suppressor gene p53 is mutated in glioblastoma. We studied the relationship between the p53 gene and the biological effects of boron neutron capture therapy (BNCT). MATERIALS AND METHODS The human glioblastoma cells; A172, expressing wild-type p53, and T98G, with mutant p53, were irradiated by the Kyoto University Research Reactor (KUR). The biological effects after n...

This study was undertaken to investigate the biological effect of monoenergetic neutrons on human lymphocyte DNA and chromosomes. Monoenergetic neutrons of 2.3, 1.0, 0.79, 0.57, 0.37 and 0.186 MeV were generated, and 252Cf neutrons and 60Co gamma-rays were also used for comparison. Biological effect was evaluated two ways. The RBE values with the comet assay were estimated as 6.3 and 5.4 at 0.3...

Background: Several landmine detection methods, based on nuclear techniques, have been suggested during the recent years. Neutron energy moderation, neutron-induced gamma emission, neutron and gamma attenuation, and fast neutron backscattering are nuclear-based methods used for landmine detection. The aim of this study is to use backscattered neutron for landmine detection. Materials ...

Background: Boron neutron capture therapy (BNCT) is a radiotherapy that combines biological targeting and high linear energy transfer. A potential therapeutic approach for non-small cell lung cancer (NSCLC) is considered. However, dose in lung tumor is not homogeneous, and it will reduce the effect of BNCT treatment. In order to improve the dose distribution of BNCT, the multi-field irradiation...

Introduction: The Monte Carlo simulation is used to enhance reliability in the experiments related to nuclear instruments. in addition, that is used to calculate the different components of the neutron and gamma ray fluxes in boron neutron capture therapy(BNCT) and neutron capture (NCT)applications. BNCT is one of the methods in radiotherapy, that is used the neutron beam for ki...

Introduction: GRID therapy is a treatment modality in which a high dose of radiation in a single fraction is given to the tumor. This technique previously was used to treat bulky tumors with orthovoltage beams. Recently, studies have been conducted to suggest that GRID therapy with megavoltage photons can be useful in palliative treatments. On the other hand, there has always ...