Aging is associated with increasing incidence of osteoporosis; a skeletal disorder characterized by compromised bone strength that may predispose patients to an increased risk of fracture. It is imperative to identify novel ways in which to attenuate such declines in the functional properties of bone. The purpose of this study was to identify, through in silico, in vitro, and in vivo approaches...

shigella and escherichia belong to the enterobacteriaceae family which are the cause for most of the diarrheal cases in the world. shigella can cause bacterial dysenteries and shigellosis. one of the most effective proteins for pathogenesis is invasion plasmid antigen c (ipac). other bacteria like enterotoxogenic (etec), enterohemorrhagic (ehec), and e.coli can also cause diarrhea and produce i...

esophagus cancer is the eighth most common cancer worldwide and particularly high in an area extending from the southern border of the caspian sea in iran across central asia to china. since information about this mysterious disease is poor, proteomics may be solving this enigma. altering gene expression in cancer cell is a remarkable indicator can be detected by proteomics techniques and bioin...

High-throughput bioinformatic analyses increasingly rely on pipeline frameworks to process sequence and metadata. Modern implementations of these frameworks differ on three key dimensions: using an implicit or explicit syntax, using a configuration, convention or class-based design paradigm and offering a command line or workbench interface. Here I survey and compare the design philosophies of ...

Background Fasting and calorie restriction cause significant metabolic changes as organisms try to maintain energy homeostasis. The mitochondrial NAD-dependent protein deacetylase Sirt3 has important metabolic effects, including promotion of fatty acid oxidation during fasting [1] and repression of glycolysis in cancer cells [2]. We sought to investigate the mechanisms by which Sirt3 is transcr...

We consider the problem of analytically evaluating semantic interoperability in large-scale networks of schemas interconnected through pairwise schema mappings. Our heuristics are based on a graphtheoretic framework capturing important statistical properties of the graphs. We validate our heuristics on a real collection of interconnected bioinformatic databases registered with the Sequence Retr...

* Author for correspondence: Department of Microbiology, Box 357242, University of Washington, Seattle, Washington 98195, Phone: 1-206-732-6122, FAX: 1-206-7326055, [email protected]. Abstract. Cells and organisms are governed by networks of genetic, physical and metabolic interactions between proteins and other their substrates, such as DNA, RNA, and other biologically important molec...

The ESSLLI course material has been compiled by Anke L ¨ udeling and Ulf Leser. Unless otherwise mentioned, the copyright lies with the individual authors of the material. Anke L ¨ udeling and Ulf Leser declare that they have obtained all necessary permissions for the distribution of this material. ESSLLI 2008 and its organizers take no legal responsibility for the contents of this booklet. In ...