OWING to the association between alcohol and chronic pancreatitis in man' there has,been considerable interest in the effect of alcohol upon gastro-entero pancreatic (GEP) hormones. Previous estimations of GEP hormones following oral alcohol ingestion have shown raised serum gastrin concentrations in response to 18 per cent and 15 per cent ethanol in man (Becker, Reeder and Thompson2), and Stra...

Patients with the short bowel syndrome are usually afflicted by chronic diarrhoea and treated with opiate drugs, yet little documentation of the effects of such drugs on digestive function is available. In the present study we found that acute oral administration of loperamide resulted in 50% inhibition of postprandial trypsin and bilirubin output in patients with short bowel syndrome. These ch...

Many peptides are synthesized and released from the gastrointestinal tract and pancreas, including pancreatic polypeptide (PP) and the products of the gastrointestinal L cells, glucagon-like peptide 1 (GLP-1), oxyntomodulin, and peptide YY (PYY). Whereas their roles in regulation of gastrointestinal function have been known for some time, it is now evident that they also influence eating behavi...

PURPOSE Pancreatic leakage is a serious complication of gastrectomy due to stomach cancer. Therefore, we analyzed amylase and lipase concentrations in blood and drainage fluid, and evaluated the volume of drainage fluid to discern their usefulness as markers for the early detection of serious pancreatic leakage requiring reoperation after gastrectomy. METHODS From January 2001 to December 200...

CONTEXT Symptomatic pancreatic involvement in sarcoidosis is extremely rare. There are 25 reported cases of detected pancreatic sarcoidosis before death. CASE REPORT We report the case of a male patient with a history of pulmonary sarcoidosis, who presented with clinical picture and CT scan findings suggestive of pancreatic cancer. Pancreatic mass biopsy showed lesions consistent with sarcoid...

e72 Volume 35 Number 8S in severely obese diabetic patients having BS versus conventional/intensive antidiabetic therapy. Respectively, in these trials: patient numbers were 60 and 150, primary end points were 2-year HBA1C level ≤6.5% (with fasting glucose < 100 mg/dL and no anti-DM pharmacotherapy) and 1-year HBA1C levels ≤6%, and surgical interventions were gastric bypass and bilio-pancreatic...

BACKGROUND/AIMS We have investigated the effect of acute hyperglycemia on pancreaticobiliary secretion and pancreatic polypeptide (PP) release. METHODS Duodenal outputs of bilirubin, trypsin, lipase, amylase and bicarbonate were measured using a recovery marker under basal conditions and in response to modified sham feeding (MSF) in 6 healthy subjects on two separate occasions: during normogl...

During a 4-year routine screening programme for cystic fibrosis (CF) 15 464 specimens were examined for raised meconium albumin levels by a test strip method and by electroimmunoassay. The incidence of false-positive results was about 5 per 1000 specimens in either test. This could be reduced by 90% by determining the ratio of albumin : alpha-1-trypsin inhibitor (a ratio below 2.0 being conside...

BACKGROUND Pancreatic surgery remains a challenge with considerable morbidity rates. The leading cause of emergency reexploration is early postoperative hemorrhage due to technical failure of hemostasis. Failure of hemostasis is usually tackled without difficulty, except when the bleeding arises from pancreatic anastomosis, since it poses a unique surgical challenge of preserving its integrity ...

BACKGROUND It has been suggested that pancreaticogastrostomy (PG) is a safer reconstruction than pancreaticojejunostomy (PJ), resulting in lower morbidity, including lower pancreatic leak rates and decreased postoperative mortality. We compared PJ and PG after pancreaticoduodenectomy (PD). METHODS A randomized clinical trial was designed. It was stopped with 50% accrual. Patients underwent ei...