Isotopic bile salt studies have been performed in 13 cholecystectomy patients and 10 matched controls using labelled taurocholate and deoxycholic acid. Cholecystectomy subjects have reduced pools of both primary bile salts, cholate and chenodeoxycholate, while the deoxycholate pool remains normal in size. As a result of these changes, the total bile salt pool is reduced to almost half its norma...

Giardiasis, currently considered a neglected disease, is caused by the intestinal protozoan parasite Giardia duodenalis and is widely spread in human as well as domestic and wild animals. The lack of appropriate medications and the spread of resistant parasite strains urgently call for the development of novel therapeutic strategies. Host microbiota or certain probiotic strains have the capacit...

It is known that physical properties of pyridinium salts can be modulated by their chemical characteristics. Owing to their broad range of applications in biology, biotechnology and chemical research, the design and synthesis of a series of 2,4,6-triarylpyridinium salts with modified structural backbone have been carried out. The main strands of work have included modifications on pyrylium cati...

Triarylsulfonium hexafluorophosphate salts were shown to be effective catalysts for the ring-opening polymerisation of various cyclic monomers under UV irradiation. A dual basic/acidic catalytic system demonstrated the potential for UV-triggered formation of poly(δ-valerolactone)-b-poly(L-lactide)-b-poly(δ-valerolactone) in a 'one-pot' reaction.

Lymph fistula rats with either biliary fistula or pancreaticobiliary fistula were used to measure coenzyme A-independent mucosal cholesterol esterifying activity in the presence and absence of pancreatic exocrine secretion. Efficiency of pancreatic diversion was verified to minimize contamination of mucosal homogenates with adherent luminal enzyme. The synthetic activity of cholesteryl ester hy...

Tubular microporous organic networks bearing imidazolium salts (T-IM) were prepared by Sonogashira coupling of tetrakis(4-ethynylphenyl)methane and diiodoimidazolium salts, which showed promising catalytic activities in heterogeneous conversion of CO(2) into cyclic carbonates.

The kinetics of dissolution of dispersions of egg phosphatidylcholine (lecithin) by bile salts was studied by observing the decrease in turbidity as mixed micelles of lecithin and bile salt were formed. The rate of dissolution of lecithin corresponding to the formation of mixed micelles was studied in the presence of dihydroxy bile salts, sodium deoxycholate, sodium chenodeoxycholate, sodium ur...

The vesicle-to-micelle transition (VMT) was realized in catanionic surfactant systems by the addition of two kinds of bile salts, sodium cholate (SC) and sodium deoxycholate (SDC). It was found that steric interaction between the bile salt and catanionic surfactant plays an important role in catanionic surfactant systems that are usually thought to be dominated by electrostatic interaction. The...

UNLABELLED The liver bile acids transporter sodium taurocholate cotransporting polypeptide (NTCP) is responsible for the majority of sodium-dependent bile salts uptake by hepatocytes. NTCP also functions as a cellular receptor for viral entry of hepatitis B virus (HBV) and hepatitis D virus (HDV) through a specific interaction between NTCP and the pre-S1 domain of HBV large envelope protein. Ho...