Let In = {1; 2; : : : ; n} and x : In → R be a map such that ∑i∈In xi ¿ 0. (For any i, its image is denoted by xi.) Let F = {J ⊂ In : |J | = k, and ∑j∈J xj ¿ 0}. Manickam and Singhi (J. Combin. Theory Ser. A 48 (1) (1988) 91–103) have conjectured that |F|¿ ( n−1 k−1 ) whenever n¿ 4k and showed that the conclusion of the conjecture holds when k divides n. For any two integers r and ‘ let [r]‘ de...

ABTRACT The use of recombinant genetic technologies for population manipulation has mostly remained an abstract idea due to the lack of a suitable means to drive novel gene constructs to high frequency in populations. Recently Gantz and Bier showed that the use of CRISPR/Cas9 technology could provide an artificial drive mechanism, the so-called Mutagenic Chain Reaction (MCR), which could lead t...

Dear editors: Twin spotting (didymosis) means the coexistence of discrete areas of skin in close spatial and temporal proximity, differing clinically and genetically from each other, and from the background skin. This is a type of mosaicism caused by somatic recombination. A growing list of previously unexplained skin conditions has been attributed to this phenomenon.1 We describe the case of a...

A brief digression to the history of development of a method of vacuum therapy includes documentary recorded sequence of use of the low-dosed negative pressure in medical practice, including in treatment of wounds and a wound infection from the most ancient times to an era of origin of antibiotics. Evolution of technical solutions and the relation to a method which had the success and oblivion ...

Results A 35-year-old woman was diagnosed with deep vein thrombosis during her first pregnancy. She came to our out-patient department (OPD) because of swelling and a painful sensation in her left lower limb and legs, accompanied by skin color change. Heparin was prescribed before admission. Physical examinations revealed irregular borders against a background of blanching erythema on the patie...

background lumbar plexus block (lpb) is one of the anesthetic options in the elderly patients undergoing hip surgeries. lpb could be safe because it targets somatic nerve in psoas region. effectiveness of lpb is attributed to the sufficient analgesia provided intraoperatively as well as postoperatively. adequate muscle relaxation and immobility during surgery refers to its acceptability. object...