OBJECTIVE To assess the antimutagenicity of antioxidant vitamins (vitamins A, C, and E) as expressed by their efficacy to lower aflatoxin-induced mutations. METHODS The Muller-5 method for mutation detection was used to assay the frequency of X-chromosome linked recessive lethal mutations (XRLMs) in Drosophila. Larvae were exposed to dietary concentration of aflatoxins and/or the human therap...

We have developed a new method to directly measure the concentration of the particulate and dissolved pools of B-vitamins in seawater. B-vitamins are coenzymes required for life, yet many organisms cannot synthesize these compounds de novo and must scavenge them from the environment. It has been shown that B-vitamins can control the marine microbial community’s structure and activity; however, ...

Vitamins are essential for improving and maintaining human health, and the main source of vitamins is the diet. Measurement of the quantities of water-soluble vitamins in common food materials is important to understand the impact of vitamin intake on human health, and also to provide necessary information for regulators to determine adequate intakes. Liquid chromatography (LC) and mass spectro...

OBJECTIVE To summarize results of clinical trials investigating the role of homocysteine (tHcy) as a risk factor for coronary artery disease (CAD) and the role of vitamin therapy (folic acid and vitamins B6 and B12) in primary and secondary prevention of CAD. QUALITY OF EVIDENCE MEDLINE was searched from January 1976 to January 1999 to locate cross-sectional, retrospective and prospective coh...

The present study aims to ascertain whether dietary administration of a mixture of vitamins C and E may prevent the negative effects of paternal age on male fertility variables in the mouse. Experimental males were fed a standard diet supplemented with either a low or high dose of vitamins C and E. Oocytes enclosed in cumulus masses were inseminated using a 2 x 2 factorial design established ac...

The biofortification of staple crops with vitamins is an attractive strategy to increase the nutritional quality of human food, particularly in areas where the population subsists on a cereal-based diet. Unlike other approaches, biofortification is sustainable and does not require anything more than a standard food-distribution infrastructure. The health-promoting effects of vitamins depend on ...